Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,860 questions · 64,864 findings · 4,913 reviews · Headline outcomes only

No studies found 13,869 · 21.4%GRADE not reported 3,491 · 5.4%Very low 16,300 · 25.1%Low 17,338 · 26.7%Moderate 10,900 · 16.8%High 2,966 · 4.6%

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Metformin vs megestrol

Abnormal uterine bleeding · endometrial hyperplasia

It is very uncertain whether summary of findings table ‐ Metformin changes abnormal uterine bleeding compared with megestrol (very low certainty).

1 finding from 1 review

Metformin vs megestrol

Adverse effects during treatment ‐ not reported · endometrial hyperplasia

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Metformin + megestrol vs megestrol

Regression of endometrial hyperplasia (with or without atypia) to proliferative, secretory, or atrophic endometrium · endometrial hyerplasia

Summary of findings table ‐ Metformin + megestrol may leads to higher regression of endometrial hyperplasia (with or without atypia) to… compared with megestrol (low certainty).

1 finding from 1 review

Probiotics vs placebo

Proven sepsis (positive bacterial culture, local or systemic) · neonates born from 35 weeks of gestation who have underdone gastrointestinal surgery

Summary of findings table ‐ Probiotics showed no clear difference in proven sepsis (positive bacterial culture, local or systemic) compared with placebo (low certainty).

1 finding from 1 review

Intervention not reported

Health‐related quality of life · participants living with overweight or obesity

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

All‐cause mortality · participants living with overweight or obesity

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Morbidity · participants living with overweight or obesity

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Anthropometric measures other than body weight a) BMI b) Waist circumference c) Fat mass · participants living with overweight or obesity
1 finding from 1 review

Structured risk assessment vs usual care

Use of coercive measure: use of seclusion room (participants) · aggressive behaviour in schizophrenia

Structured risk assessment showed no clear difference in use of coercive measure: use of seclusion room (participants) compared with standard professional care (low certainty).

1 finding from 1 review