Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
In the maxilla, spontaneous space closure occurred in about 85% of cases (9 studies; prevalence not GRADE-rated).
3 findings from 1 review
Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review
Plaque index (PI) / oral hygiene · Children and/or adolescents (<18 years) without background systemic disease
In a subgroup analysis, milk-based probiotics reduced the bacterial plaque index more than other presentations (MD -0.10, 95%CI -0.20 to -0.00; p-interaction=0.01); not GRADE-rated.
1 finding from 1 review
Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review
In 1 study, people complained about a transient bitter taste associated with SDF (with no associated data), with no other adverse effects. In another study, there were no adverse effects. No studies reported this…
2 studies · 336 participants
Very low
Adverse effects · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review
ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Facemask with rapid maxillary expansion (RME) showed no clear difference in ANB compared with reverse chin cup; GRADE not reported.
1 finding from 1 review
Dental caries · Children (<18 years) with vs without dental caries
BsmI(rs1544410) allele distribution (G vs A) was not significantly associated with caries (OR 1.56; high heterogeneity); ungraded.
1 finding from 1 review
Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
It is very uncertain whether vasodilators (isoxsuprine, xanthinol nicotinate) changes maximal mouth opening (interincisal distance) compared with placebo or no active treatment (very low certainty).
2 findings from 1 review
Recurrence · People with temporomandibular disorders (TMD)
The review found no eligible studies for this question.
1 finding from 1 review
Intervention not reported
Serum vitamin D (25(OH)D): ECC vs caries-free
The intervention led to lower serum vitamin D (25(OH)D): ECC vs caries-free; GRADE not reported.
1 finding from 1 review
Dental caries · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age
The review found no eligible studies for this question.
2 findings from 1 review
dmfs was listed in the SoF table but not assessed (not reported for this comparison).
0 studies
No studies found
The mean dmft index score was 0.52 (standard care) versus 0 (advice + treatment group); relative effect not estimable; 50 participants (1 study); very low-certainty evidence.
1 study · 50 participants
Very low
Dental pain or sensitivity · Children and adults (with or without carious lesions)
It is very uncertain whether silver diamine fluoride (SDF) changes dental pain or sensitivity compared with atraumatic restorative treatment (ART) with glass ionomer cement… (very low certainty).
1 finding from 1 review
Caries arrest · Children and adults (with or without carious lesions)
1 finding from 1 review
In 1 study (45 children), 4 applications of 38% SDF at 1-monthly intervals resulted in fewer surfaces with active caries compared with 2 applications at 6-monthly intervals (MD 1.04 surfaces, 95% CI 0.23 to 1.85), and…
4 studies · 1360 participants
Very low
Swelling (mean) · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement)
Postoperative systemic antibiotics… showed no clear difference in swelling at 48 hours compared with matched placebo, partial or total chemo-mechanical debridement and…; GRADE not reported.
4 findings from 1 review
SMD 0.04 [-0.47, 0.55]
2 studies · 61 participants
GRADE not reported
SMD 0.27 [-0.23, 0.78]
2 studies · 62 participants
Very low
SMD 0.02 [-0.49, 0.52]
2 studies · 61 participants
Very low
Show 1 more finding
Enamel demineralization (DIAGNOdent score) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)
A single triple-blinded RCT found the ACP-containing adhesive reduced enamel demineralization versus a conventional adhesive over 6 months (ungraded).
1 finding from 1 review
Recurrence · People with temporomandibular disorders (TMD)
The review found no eligible studies for this question.
1 finding from 1 review
Dental service utilisation within the past year · Adult residents of slums and non-slum urban settings of LMICs
Past-year dental service use varies widely (4%-72%); ungraded.
1 finding from 1 review
Patient discomfort · People with temporomandibular disorders (TMD)
The review found no eligible studies for this question.
1 finding from 1 review
ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Tandem traction bow appliance led to higher ANB compared with untreated control (no treatment); GRADE not reported.
1 finding from 1 review
Caries arrestment at the surface level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
Pooling two highly heterogeneous trials, SDF showed no significant difference versus 5% sodium fluoride varnish in surface-level caries arrestment (OR 1.46; ungraded subgroup).
1 finding from 1 review