Question · asked by 1 review
Postoperative systemic antibiotics (phenoxymethylpenicillin/penicillin VK, 7-day course), partial or total chemo-mechanical debridement and analgesics vs Matched placebo, partial or total chemo-mechanical debridement and analgesics: Swelling (mean)
- Population
- Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement)
- Intervention
- Postoperative systemic antibiotics (phenoxymethylpenicillin/penicillin VK, 7-day course), partial or total chemo-mechanical debridement and analgesics
- Comparison
- Matched placebo, partial or total chemo-mechanical debridement and analgesics
- Outcome
- Swelling (mean)
Postoperative systemic antibiotics… showed no clear difference in swelling at 48 hours compared with matched placebo, partial or total chemo-mechanical debridement and…; GRADE not reported.
What each review found
Include earlier review versionsNo studies found 0 · 0%GRADE not reported 1 · 25%Very low 3 · 75%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Postoperative systemic antibiotics (phenoxymethylpenicillin/penicillin VK, 7-day course), partial or total chemo-mechanical debridement and analgesics vs Matched placebo, partial or total chemo-mechanical debridement and analgesics Swelling at 48 hours · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or… · 48 hours Postoperative systemic antibiotics… showed no clear difference in swelling at 48 hours compared with matched placebo, partial or total chemo-mechanical debridement and…; GRADE not reported. Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults (2024) · Cochrane All outcomes | SMD 0.04 [-0.47, 0.55] | 2 studies · 61 participants | GRADE not reported |
Postoperative systemic antibiotics (phenoxymethylpenicillin/penicillin VK, 7-day course), partial or total chemo-mechanical debridement and analgesics vs Matched placebo, partial or total chemo-mechanical debridement and analgesics Swelling at 24 hours · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or… · 24 hours It is very uncertain whether postoperative systemic antibiotics… changes swelling at 24 hours compared with matched placebo, partial or total chemo-mechanical debridement and… (very low certainty). Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults (2024) · Cochrane All outcomes | SMD 0.27 [-0.23, 0.78] | 2 studies · 62 participants | Very low |
Postoperative systemic antibiotics (phenoxymethylpenicillin/penicillin VK, 7-day course), partial or total chemo-mechanical debridement and analgesics vs Matched placebo, partial or total chemo-mechanical debridement and analgesics Swelling at 72 hours · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or… · 72 hours It is very uncertain whether postoperative systemic antibiotics… changes swelling at 72 hours compared with matched placebo, partial or total chemo-mechanical debridement and… (very low certainty). Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults (2024) · Cochrane All outcomes | SMD 0.02 [-0.49, 0.52] | 2 studies · 61 participants | Very low |
Postoperative systemic antibiotics (phenoxymethylpenicillin/penicillin VK, 7-day course), partial or total chemo-mechanical debridement and analgesics vs Matched placebo, partial or total chemo-mechanical debridement and analgesics Swelling at 7 days · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or… · 7 days It is very uncertain whether postoperative systemic antibiotics… changes swelling at 7 days compared with matched placebo, partial or total chemo-mechanical debridement and… (very low certainty). Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults (2024) · Cochrane All outcomes | MD 0.02 [-0.28, 0.32] | 1 study · 41 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults 2024 · Cochrane All outcomes | 2022-11 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.