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Evidence found and GRADE certainty

3,556 questions · 10,375 findings · 429 reviews · Oral Health

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No studies found 1,344 · 13%GRADE not reported 6,832 · 65.9%Very low 1,228 · 11.8%Low 613 · 5.9%Moderate 290 · 2.8%High 68 · 0.7%

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Adjunctive antimicrobial photodynamic therapy (aPDT) applied after subgingival instrumentation (SI) vs Subgingival instrumentation (SI) alone (hand or power-driven, or both), or SI plus placebo/sham aPDT

Patient satisfaction · Adults (> 18 years) with a clinical diagnosis of periodontitis, receiving active (non-surgical anti-infective) treatment

The review found no eligible studies for this question.

1 finding from 1 review

Bone-anchored intermaxillary traction (BAIMT) vs Removable mandibular retractor (RMR)

Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Bone-anchored intermaxillary traction (BAIMT) led to higher overjet compared with removable mandibular retractor (RMR); GRADE not reported.

1 finding from 1 review

Cesarean section delivery vs Vaginal delivery

Early childhood caries (ECC) · Children aged <6 years

No significant association between cesarean vs vaginal delivery and ECC among America/Canada/Brazil studies (OR 1.11, 95% CI 0.70-1.76).

17 findings from 1 review
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Postoperative systemic antibiotics (phenoxymethylpenicillin/penicillin VK, 7-day course), partial or total chemo-mechanical debridement and analgesics vs Matched placebo, partial or total chemo-mechanical debridement and analgesics

Number of ibuprofen tablets required · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement)

Postoperative systemic antibiotics… showed no clear difference in number of ibuprofen tablets required compared with matched placebo, partial or total chemo-mechanical debridement and…; GRADE not reported.

1 finding from 1 review

Orthodontic removable traction appliance (ORTA) vs no intervention

Wits appraisal · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Orthodontic removable traction appliance (ORTA) led to higher wits appraisal compared with untreated control (no treatment); GRADE not reported.

1 finding from 1 review

Adjunctive antimicrobial photodynamic therapy (aPDT) applied after subgingival instrumentation (SI) vs Subgingival instrumentation (SI) alone (hand or power-driven, or both), or SI plus placebo/sham aPDT

Any adverse effect related to aPDT · Adults (> 18 years) with a clinical diagnosis of periodontitis, receiving active (non-surgical anti-infective) treatment
1 finding from 1 review

Prophylaxis (teeth cleaning) and CHX or iodine-NaF solution application in the dentition of women (mothers) vs placebo

Mother microbiological presence · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age
1 finding from 1 review

Facemask (with frame internal fixation) vs Frankel III functional appliance

Wits appraisal · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Facemask (with frame internal fixation) showed no clear difference in wits appraisal compared with frankel III functional appliance; GRADE not reported.

1 finding from 1 review

Occlusal splint vs No treatment or placebo (non-occlusal or transparent-foil placebo splint)

Joint pain at rest · People with temporomandibular disorders (TMD)

It is very uncertain whether occlusal splint changes joint pain at rest compared with no treatment or placebo (non-occlusal or transparent-foil placebo… (very low certainty).

1 finding from 1 review

TT genotype vs TC+CC genotypes

Dental caries · Children (<18 years) with vs without dental caries

In the PCR-RFLP genotyping subgroup, TaqI(rs731236) recessive model: TT vs TC+CC showed no significant association with caries (OR 1.49); ungraded.

8 findings from 1 review
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Intralesional steroid injection plus adjunctive treatment vs steroid injection

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Intralesional steroid injection plus adjunctive treatment showed no clear difference in maximal mouth opening (interincisal distance) compared with intralesional steroid injection alone (low certainty).

2 findings from 1 review

Adjunctive antimicrobial photodynamic therapy (aPDT) applied after submucosal instrumentation (SI) vs Submucosal instrumentation (SI) alone, or SI plus placebo/sham aPDT

Quality of life · Adults (> 18 years) with peri-implant mucositis, receiving active treatment

The review found no eligible studies for this question.

1 finding from 1 review

Fixed orthodontic treatment with fixed (multibracket) appliances (exposure) vs None (single-group prevalence/incidence estimate)

Incidence of new ICLs (mean number of new lesions per subject) · Patients undergoing fixed orthodontic treatment with fixed (multibracket) appliances, followed for development of new ICLs

Patients developed on average about 2.29 new ICLs during fixed orthodontic treatment (95% CI 1.12-3.46; very low certainty; very high heterogeneity).

1 finding from 1 review

Topical curcumin gel vs Topical aloe vera gel

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

It is very uncertain whether topical curcumin gel changes maximal mouth opening (interincisal distance) compared with topical aloe vera gel (very low certainty).

1 finding from 1 review

One-step adhesive bonding system (GC Ortho Connect) vs Conventional three-step bonding system (3M Transbond XT)

White spot lesion incidence, area, and depth · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

GC Ortho Connect had more frequent, larger, and deeper WSLs, with certainty not graded.

1 finding from 1 review

Package of oral health education/promotion including oral hygiene advice for pregnant women, mothers, infants and young children, plus dietary and feeding practice advice for infants and young children vs usual care

Caries presence in top front four teeth · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…

It is very uncertain whether package of oral health education/promotion including oral hygiene… changes caries presence in top front four teeth compared with standard care (very low certainty).

1 finding from 1 review

Fixed orthodontic treatment with fixed (multibracket) appliances (exposure) vs None (single-group prevalence/incidence estimate)

Prevalence of ICLs (mean number of lesions per subject) · Patients (permanent dentition) during or after fixed orthodontic treatment with fixed (multibracket) appliances

Patients had on average about 2.24 ICLs per subject during/after fixed orthodontic treatment (95% CI 1.79-2.70; very low certainty; very high heterogeneity).

1 finding from 1 review

Non-syndromic cleft lip and palate (CLP) status and its oral microbiota (exposure/grouping) vs Children and adolescents aged 0-18 years without CLP (controls)

Dental caries · Children and adolescents aged 0-18 years with non-syndromic cleft lip and palate (CLP)

Pooling 3 studies, children/adolescents with CLP were about 2.03 times more likely to have dental caries than non-CLP controls (p<0.005; low heterogeneity), though most included studies were at high risk of bias; the evidence is ungraded.

1 finding from 1 review