Findings

What do systematic reviews say?

3,535 questions · 3,601 findings · 252 reviews · Pregnancy and Childbirth

Sort:Best matchNewestHighest certainty Download CSV

No studies found 726 · 20.2%GRADE not reported 421 · 11.7%Very low 828 · 23%Low 993 · 27.6%Moderate 486 · 13.5%High 147 · 4.1%

Oral misoprostol one‐ to two‐hourly vs oral misoprostol four‐ to six‐hourly

Admission to neonatal intensive care unit · women in the third trimester for induction of labour with intact membranes

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 64 participants
Very low

Oral misoprostol 20 µg hourly titrated vs oral misoprostol 25 µg two‐hourly static

Vaginal birth within 24 hours · induction of labour.

Oral misoprostol 20 µg hourly titrated showed no clear difference in vaginal birth within 24 hours compared with oral misoprostol 25 µg two‐hourly static (low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.97 [0.8, 1.16]
2 studies · 296 participants
Low

Oral misoprostol 20 µg hourly titrated vs oral misoprostol 25 µg two‐hourly static

Caesarean section · induction of labour.

It is very uncertain whether oral misoprostol 20 µg hourly titrated changes caesarean section compared with oral misoprostol 25 µg two‐hourly static (very low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 1.66 [0.63, 4.32]
2 studies · 296 participants
Very low

Oral misoprostol 20 µg hourly titrated vs oral misoprostol 25 µg two‐hourly static

Uterine hyperstimulation with fetal heart rate changes · induction of labour.

It is very uncertain whether oral misoprostol 20 µg hourly titrated changes uterine hyperstimulation with FHR changes compared with oral misoprostol 25 µg two‐hourly static (very low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 3 [0.12, 72.45]
1 study · 146 participants
Very low

Oral misoprostol 20 µg hourly titrated vs oral misoprostol 25 µg two‐hourly static

Oxytocin augmentation · induction of labour.

It is very uncertain whether oral misoprostol 20 µg hourly titrated changes oxytocin augmentation compared with oral misoprostol 25 µg two‐hourly static (very low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 1.04 [0.85, 1.27]
2 studies · 296 participants
Very low

Oral misoprostol 20 µg hourly titrated vs oral misoprostol 25 µg two‐hourly static

Uterine hyperstimulation without fetal heart rate changes · induction of labour.

It is very uncertain whether oral misoprostol 20 µg hourly titrated changes uterine hyperstimulation without FHR changes compared with oral misoprostol 25 µg two‐hourly static (very low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 4 [0.88, 18.2]
1 study · 146 participants
Very low

Oral misoprostol 20 µg hourly titrated vs oral misoprostol 25 µg two‐hourly static

Apgar score less than 7 at 5 minutes · induction of labour.

It is very uncertain whether oral misoprostol 20 µg hourly titrated changes apgar score less than 7 at 5 minutes compared with oral misoprostol 25 µg two‐hourly static (very low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 1 [0.32, 3.16]
2 studies · 296 participants
Very low

Oral misoprostol 20 µg hourly titrated vs oral misoprostol 25 µg two‐hourly static

Admission to neonatal intensive care unit · induction of labour.

It is very uncertain whether oral misoprostol 20 µg hourly titrated changes admission to NICU compared with oral misoprostol 25 µg two‐hourly static (very low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 1.38 [0.57, 3.31]
2 studies · 296 participants
Very low

Oral misoprostol vs placebo/no treatment

Uterine hyperstimulation without fetal heart rate changes · women with ruptured membranes in the third trimester for induction of labour.

It is very uncertain whether oral misoprostol changes uterine hyperstimulation without fetal heart rate changes compared with placebo/no treatment (very low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 2.06 [0.39, 10.87]
2 studies · 430 participants
Very low

Oral misoprostol vs placebo/no treatment

Apgar score less than 7 at 5 minutes · women with ruptured membranes in the third trimester for induction of labour.

It is very uncertain whether oral misoprostol changes apgar score less than 7 at 5 minutes compared with placebo/no treatment (very low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 1.11 [0.46, 2.66]
3 studies · 495 participants
Very low

Oral misoprostol vs placebo/no treatment

Admission to neonatal intensive care unit · women with ruptured membranes in the third trimester for induction of labour.

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 130 participants
Very low

Oral misoprostol vs vaginal dinoprostone

Vaginal birth within 24 hours · women in the third trimester for induction of labour.

Oral misoprostol showed no clear difference in vaginal birth within 24 hours compared with vaginal dinoprostone (low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.93 [0.87, 1]
10 studies · 8983 participants
Low

Oral misoprostol vs vaginal dinoprostone

Caesarean section · women in the third trimester for induction of labour.

Oral misoprostol probably leads to lower caesarean section compared with vaginal dinoprostone (moderate certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.84 [0.78, 0.9]
13 studies · 9676 participants
Moderate

First trimester routine vs selective ultrasound

Maternal anxiety3 · Fetal ultrasound assessment before 24 weeks' gestation

First trimester routine probably leads to lower maternal anxiety3 compared with selective ultrasound (moderate certainty).

1 finding from 1 review

Routine ultrasound for fetal assessment before 24 weeks' gestation 2021 · Cochrane Headline outcomes only
RR 0.8 [0.65, 0.99]
1 study · 634 participants
Moderate

Second trimester routine vs selective ultrasound

Preterm birth less than 34 weeks' gestation · Fetal ultrasound assessment before 24 weeks' gestation

1 finding from 1 review

Routine ultrasound for fetal assessment before 24 weeks' gestation 2021 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

First trimester routine vs selective ultrasound

Perinatal loss · Fetal ultrasound assessment before 24 weeks' gestation

First trimester routine showed no clear difference in perinatal loss compared with selective ultrasound (low certainty).

1 finding from 1 review

Routine ultrasound for fetal assessment before 24 weeks' gestation 2021 · Cochrane Headline outcomes only
RR 0.97 [0.55, 1.73]
1 study · 648 participants
Low

First trimester routine vs selective ultrasound

Induction of labour for post‐maturity · Fetal ultrasound assessment before 24 weeks' gestation

First trimester routine showed no clear difference in induction of labour for post‐maturity compared with selective ultrasound (low certainty).

1 finding from 1 review

Routine ultrasound for fetal assessment before 24 weeks' gestation 2021 · Cochrane Headline outcomes only
RR 0.83 [0.5, 1.37]
3 studies · 1474 participants
Low

First trimester routine vs selective ultrasound

Termination for major abnormality · Fetal ultrasound assessment before 24 weeks' gestation

1 finding from 1 review

Routine ultrasound for fetal assessment before 24 weeks' gestation 2021 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

First trimester routine vs selective ultrasound

Preterm birth less than 34 weeks' gestation · Fetal ultrasound assessment before 24 weeks' gestation

1 finding from 1 review

Routine ultrasound for fetal assessment before 24 weeks' gestation 2021 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Second trimester routine vs selective ultrasound

Perinatal loss · Fetal ultrasound assessment before 24 weeks' gestation

Second trimester routine showed no clear difference in perinatal loss compared with selective ultrasound (moderate certainty).

1 finding from 1 review

Routine ultrasound for fetal assessment before 24 weeks' gestation 2021 · Cochrane Headline outcomes only
RR 0.98 [0.81, 1.2]
3 studies · 17918 participants
Moderate