Question · asked by 1 review

Oral misoprostol 20 µg hourly titrated vs oral misoprostol 25 µg two‐hourly static: Caesarean section

Population
induction of labour.
Intervention
Oral misoprostol 20 µg hourly titrated
Comparison
oral misoprostol 25 µg two‐hourly static
Outcome
Caesarean section

It is very uncertain whether oral misoprostol 20 µg hourly titrated changes caesarean section compared with oral misoprostol 25 µg two‐hourly static (very low certainty).

What each review found

Include earlier review versions
FindingEffectStudiesGRADE certainty
Oral misoprostol 20 µg hourly titrated vs oral misoprostol 25 µg two‐hourly static
Caesarean section · induction of labour.
It is very uncertain whether oral misoprostol 20 µg hourly titrated changes caesarean section compared with oral misoprostol 25 µg two‐hourly static (very low certainty).
Low‐dose oral misoprostol for induction of labour (2021) · Cochrane Headline outcomes only
RR 1.66 [0.63, 4.32]2 studies · 296 participantsVery low

Findings are shown side by side, never pooled across reviews.

The reviews

ReviewSearched up toIncluded studiesAMSTAR 2
Low‐dose oral misoprostol for induction of labour
2021 · Cochrane Headline outcomes only
Not reportedNot extractedNot assessed
How reviews are matched to this question

Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.