Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,444 questions · 1,518 findings · 135 reviews · Infectious Diseases

No studies found 135 · 8.9%GRADE not reported 150 · 9.9%Very low 350 · 23.1%Low 420 · 27.7%Moderate 321 · 21.1%High 142 · 9.4%

Impact of Xpert MTB/RIF vs smear microscopy

All‐cause mortality at 6 months (subgroup) · people being investigated for tuberculosis (TB)

Impact of Xpert MTB/RIF showed no clear difference in all‐cause mortality at 6 months (subgroup) compared with smear microscopy (moderate certainty).

2 findings from 1 review

Impact of Xpert MTB/RIF vs smear microscopy

Successful treatment outcome in participants treated for tuberculosis · people being investigated for tuberculosis (TB)

Impact of Xpert MTB/RIF showed no clear difference in successful treatment outcome in participants treated for tuberculosis compared with smear microscopy (moderate certainty).

1 finding from 1 review

Impact of Xpert MTB/RIF vs smear microscopy

Proportion of participants who were treated for tuberculosis · people being investigated for tuberculosis (TB)

Impact of Xpert MTB/RIF showed no clear difference in proportion of participants who were treated for tuberculosis compared with smear microscopy (moderate certainty).

1 finding from 1 review

Impact of Xpert MTB/RIF vs smear microscopy

Treated participants with bacteriological confirmation of tuberculosis · people being investigated for tuberculosis (TB)

Impact of Xpert MTB/RIF probably leads to higher treated participants with bacteriological confirmation of tuberculosis compared with smear microscopy (moderate certainty).

1 finding from 1 review

Rapid susceptibility methods vs standard methods versus placebo

Mortality (subgroup genotypic) · people with bloodstream infections

Rapid susceptibility methods showed no clear difference in mortality (subgroup genotypic) compared with standard methods versus placebo (low certainty).

1 finding from 1 review

Rapid susceptibility methods vs standard methods versus placebo

Mortality (subgroup phenotypic) · people with bloodstream infections

Rapid susceptibility methods showed no clear difference in mortality (subgroup phenotypic) compared with standard methods versus placebo (low certainty).

1 finding from 1 review

Rapid susceptibility methods vs standard methods versus placebo

Mortality (without stewardship) · people with bloodstream infections

Rapid susceptibility methods showed no clear difference in mortality (without stewardship) compared with standard methods versus placebo (low certainty).

1 finding from 1 review