MMP-8 expression/activity · Human ex vivo carious dentin under sealed cavities
MMP-8 may be higher before than after cavity sealing, but the evidence is very uncertain (very low certainty).
1 finding from 1 review
Rate of maxillary molar intrusion for correction of anterior open bite · Adolescents and adults with malocclusion undergoing fixed orthodontic appliance treatment
1 finding from 1 review
Two studies (62 participants), not pooled. Abellan 2021: no significant difference in molar intrusion at 3 months (1.25 vs 1.72 mm) or 6 months (1.09 vs 1.28 mm), nor rate per month. Hasan 2022: increased intrusion…
2 studies · 62 participants
GRADE not reported
Oral health-related quality of life · Adolescents (10-19 years)
Irregular/poor toothbrushing is associated with worse OHRQoL in adolescents (narrative synthesis; no pooled estimate or GRADE rating).
1 finding from 1 review
Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomesCommunity/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
The systematic review reports factors that physical disability, visual impairment, mental disorders, poor diet and irregular brushing negatively impact OHRQoL [36].
Studies not reported
GRADE not reported
Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in mature permanent teeth
In mature teeth, MTA probably achieves higher clinical and radiographic success than calcium hydroxide (OR 3.34, 95% CI 1.81-6.17; moderate certainty).
1 finding from 1 review
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Fluoride varnish did not differ significantly from CPP-ACFP (SMD 0.18, 95% CI -0.29 to 0.64); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Oral health-related quality of life · Adolescents and adults with malocclusion undergoing orthodontic treatment with fixed or removable appliances
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in permanent teeth undergoing direct pulp capping
MTA increases clinical and radiographic success versus CH after direct pulp capping (moderate certainty).
1 finding from 1 review
Adverse events associated with treatment · Adults with oral cavity or oropharyngeal cancer
The review found no eligible studies for this question.
1 finding from 1 review
MMP-9 expression/activity · Human ex vivo carious dentin (head/neck radiotherapy)
MMP-9 showed no increase in irradiated vs non-irradiated carious dentin (one study; ungraded).
1 finding from 1 review
MMP-2 location/depth · Human ex vivo carious dentin
No clear direction of MMP-2 presence by lesion depth/location was found; the evidence is very uncertain (very low certainty).
1 finding from 1 review
Stability: Little's Irregularity Index (lower arch) · People who had received fixed appliance orthodontic treatment
Upper clear plastic retainer + lower interproximal reduction… led to lower stability: Little's Irregularity Index (lower arch) compared with positioner; GRADE not reported.
1 finding from 1 review
Smoking cessation · people who smoke
Bupropion leads to higher smoking cessation (at least six months of compared with placebo/no pharmacological treatment (high certainty).
1 finding from 1 review
Serious adverse events · people who smoke
Bupropion showed no clear difference in serious adverse events compared with placebo/no pharmacological treatment (moderate certainty).
1 finding from 1 review
Dropouts due to treatment · people who smoke
Bupropion leads to higher dropouts due to treatment compared with placebo/no pharmacological treatment (high certainty).
1 finding from 1 review
Smoking cessation · people who smoke
Bupropion plus nicotine replacement therapy (NRT) showed no clear difference in smoking cessation (at least six months of compared with NRT alone (low certainty).
1 finding from 1 review
Serious adverse events · people who smoke
Bupropion plus nicotine replacement therapy (NRT) showed no clear difference in serious adverse events compared with NRT alone (low certainty).
1 finding from 1 review
Dropouts due to treatment · people who smoke
Bupropion plus nicotine replacement therapy (NRT) showed no clear difference in dropouts due to treatment compared with NRT alone (low certainty).
1 finding from 1 review
Smoking cessation · people who smoke
Bupropion plus varenicline showed no clear difference in smoking cessation (at least six months of compared with varenicline alone (moderate certainty).
1 finding from 1 review
Serious adverse events · people who smoke
Bupropion plus varenicline showed no clear difference in serious adverse events compared with varenicline alone (low certainty).
1 finding from 1 review
Dropouts due to treatment · people who smoke
Bupropion plus varenicline showed no clear difference in dropouts due to treatment compared with varenicline alone (low certainty).
1 finding from 1 review