Caries arrestment at the individual (patient) level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
Pooling two trials, SDF markedly increased individual-level caries arrestment versus placebo (OR 18.10; ungraded subgroup).
1 finding from 1 review
Caries arrest · Children and adults (with or without carious lesions)
It is very uncertain whether silver diamine fluoride (SDF) changes caries arrest compared with glass ionomer cement (GIC) plus fluoride varnish (very low certainty).
1 finding from 1 review
Early childhood caries (ECC) · Preschool children (<6 years)
In cohort studies, breastfeeding for <6 vs ≥6 months was not significantly associated with early childhood caries (RR 0.97, 95% CI 0.88-1.06; ungraded).
2 findings from 1 review
Change in Mutans streptococci (MS) count in dental plaque · healthy people
Xylitol significantly reduced Mutans streptococci in dental plaque compared with no treatment (SMD -0.73, 95% CI -1.09 to -0.37; 5 trials, I2=53%; not GRADE-rated).
1 finding from 1 review
Poor (inadequate) oral hygiene (prevalence) · Children (<18 years) with intellectual and developmental disabilities (IDD) in India
Poor oral hygiene affects about 38% of children with IDD in India (pooled prevalence 0.38, 95% CI 0.21-0.59; high heterogeneity; ungraded).
1 finding from 1 review
Treatment success (caries lesion arrest or restoration survival) · Patients with deep carious lesions in permanent (mainly posterior) teeth
Minimally invasive caries removal showed a marginally higher mean restoration success rate than conventional removal (83.6% vs 75.4%), but the difference was not statistically significant (Mann-Whitney U, p > 0.05); certainty of evidence was not graded.
1 finding from 1 review
Mean success-rate percentage (unweighted study-level mean, 7 studies) MIT 83.6% vs CT 75.4% (Mann-Whitney U = 0.2, p > 0.05; not statistically significant)
7 studies · 1305 participants
GRADE not reported
Range of mandibular motion · People with temporomandibular disorders (TMD)
Occlusal splint showed no clear difference in range of mandibular motion compared with another occlusal splint with a different mechanism of action; GRADE not reported.
1 finding from 1 review
Ion release (fluoride, calcium, phosphate) · Human enamel specimens around orthodontic brackets (in vitro)
In vitro, among the 5 BAG ion-release studies only Ga-doped BAG (GaMBN, Song [31]) reported a significant increase (phosphate, up to 14 days); a general significant fluoride/calcium/phosphate increase across all 5 is not supported (ungraded).
1 finding from 1 review
Caries presence in primary teeth · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age
It is very uncertain whether oral health education/promotion (oral hygiene advice plus diet and… changes caries presence in primary teeth compared with standard care (very low certainty).
1 finding from 1 review
Streptococcus mutans count · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
nCaF2 primer differed in S. mutans count only at T1, with certainty not graded.
1 finding from 1 review
Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Facemask with rapid maxillary expansion (RME) may leads to higher overjet compared with facemask only (low certainty).
1 finding from 1 review
Participant satisfaction · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
The review found no eligible studies for this question.
1 finding from 1 review
Biofilm formation (reduction) · Streptococcus mutans (in vitro cultures and biofilms)
Grape seed extract reduces S. mutans biofilm formation in vitro (5 studies; ungraded).
1 finding from 1 review
GSE reduced biofilm formation: 89% (polymeric PAC) vs 79% (dealcoholized wine) (Daglia), inhibition at 4 mg/mL (Zhao), decreased microcolonies with 2000 ug/mL GSE + fluorinol (Furiga), reduction within 30 min…
5 studies
GRADE not reported
Alignment rate · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)
Superelastic NiTi arch wire showed no clear difference in alignment rate compared with thermoelastic NiTi arch wire (low certainty).
1 finding from 1 review
Caries in primary teeth: dmft (3 years) · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…
It is very uncertain whether advice about a healthy diet (including breastfeeding promotion and… changes dmft index score (decayed, missing, filled primary teeth; range 0-20) compared with standard care (very low certainty).
1 finding from 1 review
Biofilm formation · Streptococcus mutans (in vitro cultures and biofilms)
No meta-analysis was conducted; ten included studies reported reduced or inhibited Streptococcus mutans biofilm formation with cranberry extract or fractions.
1 finding from 1 review
no estimate extracted
10 studies
GRADE not reported
Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review
Goel 2015 (3-arm: intralesional betamethasone vs lycopene vs placebo, 90 per arm): appeared to show increased interincisal distance in both intervention groups vs placebo, but only between-group differences with no…
1 study · 180 participants
GRADE not reported
Burning sensation (VAS 0-100) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
It is very uncertain whether intralesional triamcinolone changes burning sensation (VAS 0-100) compared with intralesional triamcinolone plus salvianolic acid B (very low certainty).
2 findings from 1 review
MD -1.00 [-10.37, 8.37]
1 study · 28 participants
Very low
MD -16.30 [-28.15, -4.45]
1 study · 28 participants
Very low
Dental caries in permanent teeth · Nigerian individuals with permanent dentition (approximately 12 years and older)
In permanent dentition, high-frequency sugar consumption was associated with non-significant 15% higher odds of caries (OR 1.15, 95% CI 0.88 to 1.52), with no heterogeneity (I2=0%; ungraded).
1 finding from 1 review
Proportion of teeth with non-carious cervical lesions (NCCLs) in ancient skulls · Ancient/prehistoric human skulls (excavated/archaeological skeletal remains)
Non-carious cervical lesions affected a pooled proportion of about 0.4% of teeth in ancient skulls (4 studies; ungraded, very high heterogeneity I2=97.6%).
1 finding from 1 review