evidencegaps
Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

4,317 questions · 75,239 findings · 5,342 reviews

Sort:Best matchNewestHighest certaintyDownload CSV
No studies found 15,213 · 20.2%GRADE not reported 10,323 · 13.7%Very low 17,528 · 23.3%Low 17,951 · 23.9%Moderate 11,190 · 14.9%High 3,034 · 4%

Ranked among the 5,000 newest matching findings; add words or filters to narrow the search.

AI algorithms (predominantly CNN/deep learning) as index test vs Dental expert / visual-tactile clinical assessment (reference standard)

Specificity · Patients undergoing dental caries detection on dental images (teeth/surfaces across imaging modalities)

AI algorithms have high pooled specificity (0.90) for detecting dental caries; ungraded, with very high heterogeneity (I2>95%).

1 finding from 1 review

Genetically predicted DMFS (dental caries) vs Without dental caries (lower genetic liability)

Lacunar stroke · European-ancestry adults

Genetically predicted dental caries showed no significant causal association with lacunar stroke (ungraded MR).

1 finding from 1 review

Conventional restoration vs placebo

Treatment success (caries lesion arrest or restoration survival) · Children (aged 3-11 y) with cavitated caries lesions in primary teeth

At 6 months, conventional restorations had significantly higher treatment success than placebo (OR 44.66).

1 finding from 1 review

Resin infiltration vs Non-invasive measures (fluoride varnish/toothpaste, flossing, oral hygiene instruction, sham/standard of care)

Radiographic proximal caries lesion progression · Children and adults with non-cavitated proximal (interproximal) caries lesions in primary and/or permanent teeth (ages 3-45)

Pooling 10 trials, resin infiltration reduced radiographic proximal caries progression versus non-invasive measures (OR 0.23); this subgroup was not separately GRADE-rated.

1 finding from 1 review

Partial pulpotomy with one-unit longer follow-up vs Partial pulpotomy with one-unit shorter follow-up

Overall success (composite of clinical and radiographic success) · Adults aged 18 years or older with mature permanent teeth and carious pulp exposure

In the high-risk-study-excluded sensitivity meta-regression, longer follow-up was associated with lower success.

1 finding from 1 review

Intervention not reported

Amalgam: Preference for replacement over repair - Scenario 7: non-stable (mobile) restoration

The intervention led to higher amalgam: Preference for replacement over repair - Scenario 7:…; GRADE not reported.

1 finding from 1 review

Calcium phosphate vs control

Immediate (24 h) resin-dentin bond strength (MPa) · permanent human teeth with artificial caries-affected dentin

Calcium phosphate minus Control was -21.209 MPa (95% CI -25.954 to -16.463) at 24 h.

2 findings from 1 review

Flavonoids (e.g., quercetin, proanthocyanidin) vs No biomimetic remineralization (control)

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Etch-and-Rinse adhesive + biological ACAD protocol network, Flavonoids showed 8.438 MPa higher 24 h bond strength than Control (MD 8.438, 95% CI 2.289 to 14.587; Moderate certainty).

2 findings from 1 review

Lower unemployment rate vs Higher unemployment rate (low <=5% / medium >5-10% / high >10%)

Odds of higher caries (DMFT) category · 12-year-old children across European countries (national/regional epidemiological surveys, 2011-2022)

Unemployment rate was not independently associated with DMFT category in the adjusted model (OR 0.99, 95% CI 0.44 to 2.23); not GRADE-rated.

1 finding from 1 review