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Evidence found and GRADE certainty

3,323 questions · 5,762 findings · 263 reviews · Dental caries

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No studies found 321 · 5.6%GRADE not reported 4,450 · 77.2%Very low 455 · 7.9%Low 297 · 5.2%Moderate 200 · 3.5%High 39 · 0.7%

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Enamel matrix derivative (EMD) vs Calcium hydroxide (CH)

Outcome not reported · Children with extensive decay involving the dental pulp in primary teeth
1 finding from 1 review
  • Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
    6 and 12 months
    Direct pulp capping; overall failure RR 1.00 (0.06 to 15.50) at 6/12 months (Garrocho-Rangel 2009); no pain/soft tissue/mobility/root resorption
    1 study · 90 participants
    GRADE not reported

Women who experienced preterm birth vs Women who did not experience preterm birth (term)

Dental caries · pregnant women

Women who experienced preterm birth did not have significantly higher DMFT than those who did not (mean difference 1.56, 95% CI -0.28 to 3.41; 5 studies; I2=92%); certainty of evidence not graded.

1 finding from 1 review
  • Dental caries and preterm birth: a systematic review and meta-analysis. 2018 All outcomes
    Pregnant women assessed around delivery in observational studies across multiple countries (Mexico, Malawi, India, France, Jordan, Finland, Tanzania); mostly retrospective cohort and case-control designs
    MD 1.56 [-0.28, 3.41]
    5 studies · 2963 participants
    GRADE not reported

Radiographic caries detection (bitewing radiography) vs Reference standard (histological validation or cavity/lesion opening; advanced = cavitated/dentin-involved lesions, all = enamel-confined initial lesions also counted)

Positive LR for detecting advanced proximal caries · Proximal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)

In the meta-analysis tailored to Germany, the positive lr of radiographic detection for advanced proximal caries was 9.82 (95% CI 7.3 to 13.3) (ungraded).

3 findings from 1 review

Populations with a lower proportion of university-educated people (<33.78% with university level) vs Populations with a higher proportion of university-educated people (>=33.78% with university level)

Caries experience (mean DMFT) · Adults aged 19-60 years

The proportion of university-educated people was not associated with caries experience (DMFT); pooled DMFT was similar across subgroups and the meta-regression was non-significant; ungraded observational evidence.

5 findings from 1 review
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3Mix (ciprofloxacin + metronidazole + minocycline) vs Ciprofloxacin + ornidazole + minocycline

Outcome not reported · Children with extensive decay involving the dental pulp in primary teeth

The review found no eligible studies for this question.

1 finding from 1 review

Radiographic caries detection (bitewing radiography) vs Reference standard (histological validation or cavity/lesion opening; advanced = cavitated/dentin-involved lesions, all = enamel-confined initial lesions also counted)

Specificity for detecting advanced proximal caries · Proximal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)

In the meta-analysis tailored to Egypt, pooled specificity of radiographic detection for advanced proximal caries was 95.5% (95% CI 94 to 97) (ungraded).

3 findings from 1 review

Visual caries detection (ICDAS visual/visual-tactile inspection) vs Reference standard (histological validation or cavity/lesion opening; advanced = cavitated/dentin-involved lesions, all = enamel-confined initial lesions also counted)

Negative LR for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)

In the conventional (all-studies) meta-analysis, the negative lr of visual detection for all (initial and advanced) occlusal caries was 0.19 (95% CI 0.15 to 0.25) (ungraded).

3 findings from 1 review

Glutaraldehyde + calcium hydroxide (CH) vs Full strength formocresol (FC)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Glutaraldehyde + calcium hydroxide (CH) showed no clear difference in radiological failure compared with full strength formocresol (FC); GRADE not reported.

1 finding from 1 review

Slow-release fluoride device (fluoride glass beads) vs placebo or usual care

Caries increment, surface index D(M)FS · Children with high risk of dental decay

It is very uncertain whether slow-release fluoride device (fluoride glass beads) changes increase in DMFS at 2 years compared with baseline compared with placebo or usual care (control) (very low certainty).

1 finding from 1 review

Post-secondary education vs University education

Prevalence of untreated decay (% DT > 0) · Adults aged 25 years and older in Australia, Canada, New Zealand, and the United States

In Canada, post-secondary versus university education differed by 7.8 percentage points in prevalence of untreated decay.

4 findings from 1 review
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Placebo vs no treatment

Caries increment in permanent teeth · Children or adolescents

The NMR reported an SMD by randomisation year; no GRADE assessment was reported.

1 finding from 1 review

Radiographic caries detection (bitewing radiography) vs Reference standard (histological validation or cavity/lesion opening; advanced = cavitated/dentin-involved lesions, all = enamel-confined initial lesions also counted)

Positive LR for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)

In the conventional (all-studies) meta-analysis, the positive lr of radiographic detection for all (initial and advanced) occlusal caries was 1.74 (95% CI 1.3 to 2.4) (ungraded).

3 findings from 1 review

Mineral trioxide aggregate (MTA) + sodium hypochlorite (NaOCl) vs Calcium hydroxide + sodium hypochlorite (NaOCl)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Mineral trioxide aggregate (MTA) + sodium hypochlorite (NaOCl) showed no clear difference in radiological failure compared with calcium hydroxide + sodium hypochlorite (NaOCl); GRADE not reported.

1 finding from 1 review

Sealapex (eugenol-free calcium hydroxide) vs Zinc oxide and eugenol (ZOE)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Sealapex (eugenol-free calcium hydroxide) showed no clear difference in radiological failure compared with zinc oxide and eugenol (ZOE); GRADE not reported.

1 finding from 1 review

Radiographic caries detection (bitewing radiography) vs Reference standard (histological validation or cavity/lesion opening; advanced = cavitated/dentin-involved lesions, all = enamel-confined initial lesions also counted)

Negative LR for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)

In the conventional (all-studies) meta-analysis, the negative lr of radiographic detection for all (initial and advanced) occlusal caries was 0.79 (95% CI 0.65 to 0.96) (ungraded).

3 findings from 1 review