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Enamel matrix derivative (EMD) led to lower radiological failure compared with formocresol (FC); GRADE not reported.
Pooled caries experience (DMFT) was similar in very-high-HDI and high-HDI countries, and meta-regression found no significant association between national HDI and DMFT; ungraded observational evidence with very high heterogeneity.
Biodentine showed no clear difference in radiological failure compared with tempophore; GRADE not reported.
In the meta-analysis tailored to Egypt, the negative lr of radiographic detection for all (initial and advanced) proximal caries was 0.65 (95% CI 0.57 to 0.74) (ungraded).
Vitapex (calcium hydroxide/iodoform) showed no clear difference in radiological failure compared with RC Fill; GRADE not reported.
Ferric sulphate (FS) showed no clear difference in radiological failure compared with ankaferd Blood Stopper (ABS) (low certainty).
In the illustrative network meta-regression the SMD for caries increment differed between fluoride in dentifrice and no treatment at every displayed randomization year; certainty was not graded.
Across four countries, low versus high income differed by 0.44 decayed teeth in mean number of decayed teeth (random-effects meta-analysis; I2=76.4%).
Populations with a higher proportion of people with low socioeconomic status had higher caries experience (pooled DMFT 15.99 vs 5.50), and meta-regression associated low SES with higher DMFT (about 10.35 more DMFT per unit; p=0.050); ungraded observational evidence.
The review found no eligible studies for this question.
CRT with compomer ranked first for treatment success in the occlusal-surface network (low certainty).
It is very uncertain whether 3Mix (ciprofloxacin + metronidazole + minocycline) changes clinical failure compared with simvastatin (very low certainty).
Aloe vera led to higher clinical failure compared with mineral trioxide aggregate (MTA); GRADE not reported.
Two trials reported visual inspection scores but could not be pooled (different criteria, missing standard deviations) and gave inconsistent findings, so no quantitative conclusion could be drawn.
Calcium hydroxide/iodoform (CH/iodoform) led to higher radiological failure compared with full strength formocresol (FC); GRADE not reported.
The Model 1 adjusted meta-regression coefficient for quantitative HDI was -42.94101.
In Canada, secondary versus university education differed by 0.7 decayed teeth in mean number of decayed teeth.
Low-level diode laser showed no clear difference in overall failure compared with mineral trioxide aggregate (MTA); GRADE not reported.
It is very uncertain whether self-etch adhesive + acetone-based total-etch adhesive changes clinical failure compared with acetone-based total-etch adhesive (very low certainty).
Postnatal (infancy) tobacco exposure is associated with higher odds of caries in permanent dentition (pooled OR 1.30, 95% CI 1.25 to 1.34; 9 studies; no heterogeneity); certainty not graded.