Arrest or reversal of noncavitated facial/lingual carious lesions · Children and adults with noncavitated carious lesions on facial/lingual surfaces (primary and permanent teeth)
1.23% APF gel + oral health education was probably more effective than Oral health education for arrest or reversal of facial/lingual carious lesions (RR 2.47, 95% CI 1.95 to 3.13; moderate certainty).
1 finding from 1 review
Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
1000 to 1250 ppm F toothpaste showed no clear difference in caries increment, surface index D(M)FS compared with 440 to 550 ppm F toothpaste (low certainty).
1 finding from 1 review
SMD -0.16 [-0.35, 0.03]
1 study
Low
Proportion developing new caries · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
1450 to 1500 ppm F toothpaste showed no clear difference in proportion developing new caries compared with 1000 to 1250 ppm F toothpaste (low certainty).
1 finding from 1 review
Number of participants with new demineralised lesions (DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
It is very uncertain whether patient-used 250 ppm F mouthrinse (100 ppm amine F/150 ppm NaF), daily changes number of participants with new demineralised lesions (DLs) compared with 0 ppm F placebo mouthrinse, daily (very low certainty).
1 finding from 1 review
Intervention not reported
Marginal restoration discoloration (adverse event)
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Pain · Children with carious vital pulp exposure in primary incisors
No statistically significant difference in pain between pulpotomy and pulpectomy (RR 2.06, 95% CI 0.31 to 13.8; ungraded).
1 finding from 1 review
RR 2.06 [0.31, 13.8]
Studies not reported
GRADE not reported
Side effects · Adults, 16 years and older (dentate)
The review found no eligible studies for this question.
1 finding from 1 review
Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth)
0.2% NaF mouthrinse + supervised toothbrushing was probably less effective than Resin infiltration + 5% NaF varnish for arrest or reversal of occlusal carious lesions (RR 0.61, 95% CI 0.43 to 0.85; moderate certainty).
1 finding from 1 review
DMFT/DMFS index (dental caries experience) · Children aged 0-12 years (studies published before 2015)
In studies published before 2015, OHPPs were associated with lower DMFT (OR 0.01, 95% CI 0.00 to 0.13; ungraded).
1 finding from 1 review
Coronal carious lesions arrest · Children with coronal carious lesions (primary dentition)
Across three reviews, 38% SDF arrested 65 to 91% of coronal lesions in primary teeth, outperforming fluoride varnish (38 to 44%), glass ionomer cement (39 to 82%), and placebo (34%) (ungraded).
1 finding from 1 review
Arrest rate 65–91
6 studies
GRADE not reported
Caries increment, surface index D(M)FS · Adults with mature permanent dentition (aged 18 to 93 years at study start)
1000 or 1100 ppm F toothpaste probably leads to lower caries increment, surface index DMFS compared with non-fluoride (0 ppm F) placebo toothpaste (moderate certainty).
1 finding from 1 review
Proportion developing new caries · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
1450 to 1500 ppm F toothpaste may leads to lower proportion developing new caries compared with non-fluoride (0 ppm F) placebo toothpaste (low certainty).
1 finding from 1 review
Pulp canal obliteration · Children with carious vital pulp exposure in primary incisors
Pulp canal obliteration was reported narratively (mainly in the pulpotomy group) and was not pooled.
1 finding from 1 review
Intervention not reported
Clinical and radiographic success
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Oral health-related quality of life · Children and adolescents with juvenile idiopathic arthritis (JIA)
Evidence on OHRQoL was limited: one study found no significant difference between groups while another found orofacial symptoms affected daily life more in JIA; no pooled estimate (ungraded).
1 finding from 1 review
Santos et al. [29] found oral health status had little or no effect on well-being with no significant difference between JIA and healthy groups (SF:13-B-PCPQ); Leksell et al. [38] found orofacial symptoms influenced…
2 studies · 111 participants
GRADE not reported
Side effects · Adults, 16 years and older (dentate)
1 finding from 1 review
Arrest or reversal of noncavitated carious lesions on any coronal surface · Children and adults with noncavitated carious lesions on any coronal surface (primary and permanent teeth)
10% CPP-ACP paste was probably less effective than 5% NaF varnish for arrest or reversal of any-coronal carious lesions (RR 0.48, 95% CI 0.38 to 0.6; moderate certainty).
1 finding from 1 review
Plaque index (PI) / oral hygiene · Children and adolescents with juvenile idiopathic arthritis (JIA)
Evidence on oral hygiene/dental plaque was inconsistent: several studies found higher plaque in the JIA group while others found no difference; no pooled estimate (ungraded).
1 finding from 1 review
Some studies showed a statistically higher Plaque Index or Simplified Oral Hygiene Index (OHI-S) in the JIA group [23, 25, 28, 31]; other studies did not find this association [22, 26, 27, 29, 30, 39]. Meta-analysis…
Studies not reported
GRADE not reported
Plaque · Adults, 16 years and older (dentate)
It is very uncertain whether oral irrigation plus toothbrushing changes plaque compared with flossing plus toothbrushing (very low certainty).
1 finding from 1 review
Periodontitis (probing pocket depth) · Adults, 16 years and older (dentate)
1 finding from 1 review