Adverse events: black staining of arrested lesions · Children and older adults treated with SDF for carious lesions
Black staining of arrested lesions was the main adverse event of SDF (reported by seven reviews); it was generally acceptable to patients (ungraded).
1 finding from 1 review
Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
440 to 550 ppm F toothpaste showed no clear difference in caries increment, tooth index D(M)FT compared with 250 ppm F toothpaste (low certainty).
1 finding from 1 review
SMD -0.08 [-0.32, 0.17]
1 study
Low
Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
1700 to 2200 ppm F toothpaste may leads to lower caries increment, surface index D(M)FS compared with 250 ppm F toothpaste (low certainty).
1 finding from 1 review
SMD -0.17 [-0.3, -0.04]
Studies not reported
Low
Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
1000 to 1250 ppm F toothpaste leads to lower caries increment, tooth index D(M)FT compared with non-fluoride (0 ppm F) placebo toothpaste (high certainty).
1 finding from 1 review
SMD -0.26 [-0.31, -0.21]
41 studies
High
Intervention not reported
Dental caries prevalence
1 finding from 1 review
Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth)
1.23% APF gel may not differ from Sealant for arrest or reversal of occlusal carious lesions (RR 1.08, 95% CI 0.82 to 1.41; low certainty).
1 finding from 1 review
Intervention not reported
Calcific metamorphosis (adverse event)
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Number of participants with new demineralised lesions (DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
Resin-modified glass ionomer cement for bonding orthodontic brackets showed no clear difference in number of participants with new demineralised lesions (DLs) compared with light-cured composite resin for bonding brackets (low certainty).
1 finding from 1 review
Arrest or reversal of noncavitated and cavitated root carious lesions · Adults (including institutionalized/older adults) with noncavitated and cavitated carious lesions on root surfaces (permanent teeth)
5,000-ppm F (1.1% NaF) toothpaste or gel may be more effective than no treatment for arrest or reversal of root carious lesions (RR 2.62, 95% CI 1.49 to 4.63; low certainty).
1 finding from 1 review
Arrest or reversal of noncavitated carious lesions on any coronal surface · Children and adults with noncavitated carious lesions on any coronal surface (primary and permanent teeth)
1.23% APF gel may not differ from 5% NaF varnish for arrest or reversal of any-coronal carious lesions (RR 1.05, 95% CI 0.85 to 1.29; low certainty).
1 finding from 1 review
Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
It is very uncertain whether 2400 to 2800 ppm F toothpaste changes caries increment, tooth index D(M)FT compared with 1000 to 1250 ppm F toothpaste (very low certainty).
1 finding from 1 review
SMD -0.12 [-0.25, 0.01]
3 studies
Very low
Proportion developing new caries · Adults with mature permanent dentition (aged 18 to 93 years at study start)
The review found no eligible studies for this question.
1 finding from 1 review
Arrest or reversal of noncavitated and cavitated root carious lesions · Adults (including institutionalized/older adults) with noncavitated and cavitated carious lesions on root surfaces (permanent teeth)
38% SDF solution (applied annually) may not differ from 38% SDF + potassium iodide solution (applied annually) for arrest or reversal of root carious lesions (RR 0.8, 95% CI 0.25 to 2.61; low certainty).
1 finding from 1 review
Streptococcus mutans count · Medically healthy individuals (adults and children, 6-60 years)
Salvadora persica rinse reduced Streptococcus mutans counts more than placebo (favours Salvadora persica); not GRADE-rated.
1 finding from 1 review
Side effects · Adults, 16 years and older (dentate)
1 finding from 1 review
Three studies reported that there were no adverse events, one reported one incidence of aphthous ulcer in irrigator group, one reported oral lacerations but found no difference between the interventions, and one did…
5 studies
GRADE not reported
Arrest of advanced cavitated carious lesions on any coronal surface · Preschool children with advanced cavitated carious lesions on any coronal surface (primary teeth)
30% SDF solution (once weekly for 3 weeks) probably did not differ from 5% NaF varnish (once weekly for 3 weeks) for arrest or reversal of cavitated coronal carious lesions (RR 0.97, 95% CI 0.8 to 1.18; moderate certainty).
3 findings from 1 review
Arrest or reversal of noncavitated approximal carious lesions · Children and adults with noncavitated carious lesions on approximal surfaces (primary and permanent teeth)
Resin infiltration may be more effective than no treatment for arrest or reversal of approximal carious lesions (RR 2.11, 95% CI 1.08 to 4.13; low certainty).
1 finding from 1 review
Plaque · Medically healthy individuals (adults and children, 6-60 years)
Salvadora persica rinse reduced plaque more than placebo (favours Salvadora persica); certainty not GRADE-rated (Shekelle grade Ia).
1 finding from 1 review
Cost of materials · Adults or children with a Class I or Class II resin-based composite restoration in a permanent posterior tooth
1 finding from 1 review
Intervention not reported
Care index, primary teeth
1 finding from 1 review
no estimate extracted
2 studies
GRADE not reported