Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,323 questions · 5,762 findings · 263 reviews · Dental caries

No studies found 321 · 5.6%GRADE not reported 4,450 · 77.2%Very low 455 · 7.9%Low 297 · 5.2%Moderate 200 · 3.5%High 39 · 0.7%

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Chemotherapy regimen A (+/- locoregional treatment) vs Chemotherapy regimen B (+/- locoregional treatment)

Locoregional control · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
1 finding from 1 review

Rubber dam isolation and moisture control (alone or with saliva aspiration) vs Cotton rolls (with or without saliva aspiration)

Clinical evaluation of restoration's quality · Dental patients undergoing direct or indirect restorative treatment (no age or gender restriction)
1 finding from 1 review
  • Rubber dam isolation for restorative treatment in dental patients 2021 · Cochrane All outcomes
    6, 12, 18 months · Non-carious cervical lesions (composite restoration)
    Loguercio 2015: no significant differences (P>0.05) in marginal staining and marginal adaptation of NCCL restorations between rubber dam and cotton rolls/retraction cords at 6, 12 and 18 months.
    1 study · 30 participants
    GRADE not reported

Visual classification: ERK (Ekstrand-Ricketts-Kidd system) vs Reference standard (histology, excavation, radiographs/microCT, or tooth separation)

Sensitivity for detection of enamel caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review

Electrical conductance devices (electronic caries monitor (ECM) and/or CarieScan Pro), used as an adjunct to clinical oral examination vs Reference standard: histology or enhanced visual examination (with or without radiographs)

Outcome not reported · Samples with a low (<15%) prevalence of caries into dentine (d3/D3); target condition = non-cavitated enamel caries.

The review found no eligible studies for this question.

1 finding from 1 review
  • Electrical conductance for the detection of dental caries 2021 · Cochrane All outcomes
    Up to 3 months between index test and reference standard (in vivo studies)
    No eligible studies. 'No studies reported the inclusion of a low prevalence (0% to 14%) of d3/D3 of tooth surfaces'; all included studies reported d3/D3 prevalence of 15% or above, so the planned low-prevalence…
    0 studies
    No studies found

Clear aligners (Invisalign / thermoformed aligners) vs Fixed appliances

Lesion area (decalcification area, pixels) · Adults undergoing orthodontic treatment

A single study reported a larger decalcification lesion area with aligners versus fixed appliances in adults at 3 months (MD 80.50 pixels, 95% CI 60.52 to 100.48; ungraded).

1 finding from 1 review

Rubber dam isolation and moisture control (alone or with saliva aspiration) vs Cotton rolls (with or without saliva aspiration)

Participant acceptance/satisfaction · Dental patients undergoing direct or indirect restorative treatment (no age or gender restriction)
1 finding from 1 review
  • Rubber dam isolation for restorative treatment in dental patients 2021 · Cochrane All outcomes
    Non-carious cervical lesions (composite restoration)
    Evidence did not support higher acceptance/preference for rubber dam than cotton rolls (P = 0.85 from binomial test on 28 participants; very low-certainty evidence) (Loguercio 2015).
    1 study · 28 participants
    Very low

Less frequent tooth brushing (< twice daily) vs More frequent tooth brushing (>= twice daily)

Dental caries · Healthy children and adolescents in the United Arab Emirates

More frequent tooth brushing was generally protective against caries, though findings were somewhat inconsistent across studies (narrative synthesis; not GRADE-rated).

1 finding from 1 review

Concomitant (concurrent) chemoradiotherapy vs Radiotherapy alone

Overall survival, adjuvant concomitant chemoradiotherapy vs post-surgery radiotherapy alone · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

Concomitant (concurrent) chemoradiotherapy probably leads to lower overall survival, concurrent chemoradiotherapy vs radiotherapy alone… compared with radiotherapy alone (non-resectable tumours) (moderate certainty).

1 finding from 1 review

Fluorescence-based devices vs Dental imaging (analog or digital radiographs)

Difference in sensitivity · Asymptomatic children or adults suspected of enamel caries (clinical studies); extracted teeth (in vitro studies)

Fluorescence had higher sensitivity than imaging in the fully within-person analysis.

1 finding from 1 review

Coating material (bonding material or sealant) WITH fluoride release vs Coating material WITHOUT fluoride release

Initiation of white spot lesions (WSL), visual-tactile assessment · Patients of any age (11-40 years) receiving comprehensive/fixed orthodontic treatment with fixed appliances

Fluoride-releasing coating materials do not appear to reduce WSL initiation more than non-fluoride coatings (RR 0.84, not significant); certainty of evidence is very low.

1 finding from 1 review

Bleaching before resin infiltration (bleaching + infiltration) vs Resin infiltration alone

Masking effect (esthetic improvement) · Patients with dental fluorosis

Bleaching before resin infiltration did not improve masking of fluorosis compared with infiltration alone (MD -0.30, 95% CI -0.98 to 0.39; moderate certainty).

1 finding from 1 review

Lower family socioeconomic status / income vs Higher socioeconomic position

Dental caries · Healthy children and adolescents in the United Arab Emirates

Evidence on socioeconomic status/income and caries was inconsistent: some studies linked lower income to higher caries while others found no association (narrative synthesis; not GRADE-rated).

1 finding from 1 review

Fibre-optic transillumination (FOTI) vs Histological validation (in vitro) or direct visual examination after tooth separation / bioptical cavity preparation (in vivo)

detection of proximal caries · Permanent posterior teeth, proximal surfaces (in vitro extracted teeth and in vivo patients)

For fibre-optic transillumination (FOTI), studies were identified (in vitro N=4, in vivo N=3) but none had sufficiently low risk of bias and adequate reporting to be pooled; no meta-analytic estimate could be derived.

1 finding from 1 review

Sealing using sealant materials vs no treatment

Lesion progression · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…
1 finding from 1 review