Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,252 questions · 2,353 findings · 210 reviews · Neonatal

No studies found 432 · 18.4%GRADE not reported 99 · 4.2%Very low 609 · 25.9%Low 737 · 31.3%Moderate 385 · 16.4%High 91 · 3.9%

Fish oil lipid emulsion (LE) vs S‐LE

Severe (defined as stage 3 or greater) retinopathy of prematurity ‐ not reported · Parenterally fed preterm infants

All fish oil containing LE showed no clear difference in retinopathy of prematurity (≥ stage 3) compared with S‐LE (low certainty).

1 finding from 1 review

Fish oil lipid emulsion (LE) vs S‐LE

Parenteral nutrition‐associated liver disease/cholestasis · Parenterally fed preterm infants

All fish oil containing LE showed no clear difference in parenteral nutrition‐associated liver disease/cholestasis compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsion (LE) vs S‐LE

Severe (defined as stage 3 or greater) retinopathy of prematurity ‐ not reported · Parenterally fed preterm infants

It is very uncertain whether all alternative LE changes retinopathy of prematurity (≥ stage 3) compared with S‐LE (very low certainty).

1 finding from 1 review

Alternative lipid emulsion (LE) vs S‐LE

Parenteral nutrition‐associated liver disease/cholestasis · Parenterally fed preterm infants

All alternative LE showed no clear difference in parenteral nutrition‐associated liver disease/cholestasis compared with S‐LE (low certainty).

1 finding from 1 review

Bovine lung lavage surfactant extract vs modified bovine minced lung surfactant extract

Mortality before hospital discharge · Preterm infants for prevention of RDS

Bovine lung lavage surfactant extract showed no clear difference in mortality prior to discharge (from any cause) compared with modified bovine minced lung surfactant extract (moderate certainty).

1 finding from 1 review

Bovine lung lavage surfactant extract vs modified bovine minced lung surfactant extract

Death or oxygen requirement at 36 weeks' postmenstrual age · Preterm infants for treatment of RDS

Bovine lung lavage surfactant extract showed no clear difference in death or oxygen requirement at 36 weeks' postmenstrual age compared with modified bovine minced lung surfactant extract (high certainty).

1 finding from 1 review

Bovine lung lavage surfactant extract vs modified bovine minced lung surfactant extract

Pneumothorax · Preterm infants for treatment of RDS

Bovine lung lavage surfactant extract showed no clear difference in pneumothorax compared with modified bovine minced lung surfactant extract (low certainty).

1 finding from 1 review

Bovine lung lavage surfactant extract vs modified bovine minced lung surfactant extract

Pulmonary hemorrhage · Preterm infants for treatment of RDS

Bovine lung lavage surfactant extract showed no clear difference in pulmonary hemorrhage compared with modified bovine minced lung surfactant extract (moderate certainty).

1 finding from 1 review

Bovine lung lavage surfactant extract vs modified bovine minced lung surfactant extract

Severe intraventricular hemorrhage in infants who received neuroimaging · Preterm infants for treatment of RDS

Bovine lung lavage surfactant extract showed no clear difference in severe IVH in infants receiving neuroimaging compared with modified bovine minced lung surfactant extract (moderate certainty).

1 finding from 1 review

Bovine lung lavage surfactant extract vs porcine minced lung surfactant extract

Mortality before hospital discharge · Preterm infants for treatment of RDS

Bovine lung lavage surfactant extract showed no clear difference in mortality prior to discharge compared with porcine minced lung surfactant extract (low certainty).

1 finding from 1 review