Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,234 questions · 2,325 findings · 216 reviews · Airways

No studies found 249 · 10.7%GRADE not reported 107 · 4.6%Very low 276 · 11.9%Low 751 · 32.3%Moderate 718 · 30.9%High 224 · 9.6%

Anti‐leukotrienes & ICS vs same‐dose ICS

Number of participants experiencing one or more episode requiring treatment with oral steroids · children with asthma

Anti‐leukotrienes & ICS may leads to lower participants with one or more exacerbations requiring oral… compared with same dose ICS (low certainty).

1 finding from 1 review

Anti‐leukotrienes & ICS vs ICS dose increase

Number of participants experiencing one or more episode requiring treatment with oral steroids · children with asthma

Anti‐leukotrienes & ICS may leads to lower participants with one or more exacerbations requiring oral… compared with higher dose ICS (low certainty).

1 finding from 1 review

Intervention not reported

Quality of life1 Paediatric Asthma Quality of Life Questionnaire (PAQLQ). Scale from: 1 (worse) to 7 (better). · children and adolescents aged 18 years and under studies with asthma
1 finding from 1 review

Intervention not reported

Exacerbations requiring a course of oral corticosteroids · children and adolescents aged 18 years and under studies with asthma

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Urgent asthma physician visits1 Number of times the child visited a physician's office/clinic for an asthma flare up · children and adolescents aged 18 years and under studies with asthma
1 finding from 1 review

Intermittent 'as needed' ICS vs daily ICS

Number of participants experiencing one or more episode requiring treatment with oral steroids · Children and adults with persistent asthma.

Intermittent 'as needed' ICS showed no clear difference in patients with 1 or more exacerbations requiring oral corticosteroids… compared with daily ICS (low certainty).

1 finding from 1 review

Intermittent 'as needed' ICS vs daily ICS

Patients with serious adverse health events (duration 12 to 52 weeks) · Children and adults with persistent asthma.

Intermittent 'as needed' ICS showed no clear difference in patients with serious adverse health events (duration 12 to 52 weeks) compared with daily ICS (low certainty).

1 finding from 1 review

Intermittent 'as needed' ICS vs daily ICS

Patients with at least 1 exacerbation requiring emergency department/acute care visit (duration 12 to 52 weeks) · Children and adults with persistent asthma.

Intermittent 'as needed' ICS showed no clear difference in patients with at least 1 exacerbation requiring emergency… compared with daily ICS (low certainty).

1 finding from 1 review