Leflunomide vs placebo, 6 months
Withdrawals due to adverse events · patients with rheumatoid arthritis in adults
1 finding from 1 review
- no estimate extracted3 studies · 727 participantsHigh
Findings
What do systematic reviews say?
192 questions · 196 findings · 89 reviews
No studies found 31 · 15.8%GRADE not reported 18 · 9.2%Very low 68 · 34.7%Low 48 · 24.5%Moderate 24 · 12.2%High 7 · 3.6%
NSAIDs vs placebo
Withdrawals due to adverse events · adults with sickle cell disease in a vaso‐occlusive crisis
1 finding from 1 review
- Pharmacological interventions for painful sickle cell vaso‐occlusive crises in adults 2019 · Cochrane Headline outcomes onlyno estimate extracted3 studies · 93 participantsVery low
Skim milk enriched with GMP/G600 vs skim milk & lactose powder
Withdrawals due to adverse events · people with chronic gout
Skim milk enriched with GMP/G600 showed no clear difference in study withdrawals due to adverse events compared with skim milk, plus lactose powder (low certainty).
2 findings from 2 reviews · compare the 2 reviews
- RR 1.27 [0.53, 3.03]1 study · 120 participantsLow
- RR 1.27 [0.53, 3.03]1 study · 120 participantsLow
Vitamin C vs allopurinol
Withdrawals due to adverse events · participants with chronic gout and sUA level > 0.36mmol/L
1 finding from 1 review
- no estimate extracted1 study · 40 participantsLow
Paracetamol vs placebo
Withdrawals due to adverse events · Patients with osteoarthritis of the knee or hip
Paracetamol showed no clear difference in withdrawals due to adverse events 24 weeks compared with placebo (moderate certainty).
1 finding from 1 review
- RR 1.19 [0.91, 1.55]7 studies · 3023 participantsModerate
Methotrexate vs alternative disease‐modifying antirheumatic drugs
Withdrawals due to adverse events · children and young people with JIA
Methotrexate showed no clear difference in withdrawals due to adverse events(4 months) compared with alternative disease‐modifying antirheumatic drugs (low certainty).
1 finding from 1 review
- RR 0.33 [0.04, 3.09]1 study · 94 participantsLow
Inulin and oligofructose 15 g vs inulin and oligofructose 7.5 g daily
Withdrawals due to adverse events · Patients with active mild to moderate ulcerative colitis
It is very uncertain whether inulin and oligofructose 15 g changes withdrawals due to adverse events (9 weeks) compared with inulin and oligofructose 7.5 g daily (very low certainty).
1 finding from 1 review
- Prebiotics for induction and maintenance of remission in ulcerative colitis 2024 · Cochrane Headline outcomes onlyRR 0.53 [0.11, 2.5]1 study · 31 participantsVery low
Prebiotic vs probiotic
Withdrawals due to adverse events · people in remission or with mildly activeulcerative colitis
It is very uncertain whether prebiotics changes withdrawals due to adverse events (4 weeks) compared with probiotics (very low certainty).
1 finding from 1 review
- Prebiotics for induction and maintenance of remission in ulcerative colitis 2024 · Cochrane Headline outcomes onlyRR 1 [0.44, 2.26]1 study · 80 participantsVery low
Prebiotic vs synbiotics
Withdrawals due to adverse events · people in remission or with mildly activeulcerative colitis
It is very uncertain whether prebiotics changes withdrawals due to adverse events (4 weeks) compared with synbiotics (very low certainty).
1 finding from 1 review
- Prebiotics for induction and maintenance of remission in ulcerative colitis 2024 · Cochrane Headline outcomes onlyRR 1.13 [0.48, 2.62]1 study · 80 participantsVery low
Ultrasound‐guided injection vs non‐image‐guided injection
Withdrawals due to adverse events · Patients with shoulder pain
The review found no eligible studies for this question.
1 finding from 1 review
- Image‐guided glucocorticoid injection versus injection without image guidance for shoulder pain 2021 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Naftopidil vs Eviprostat (phytotherapy)
Withdrawals due to adverse events
It is very uncertain whether naftopidil changes treatment withdrawals due to adverse events compared with eviprostat (phytotherapy) (very low certainty).
1 finding from 1 review
- Naftopidil for the treatment of lower urinary tract symptoms compatible with benign prostatic hyperplasia 2018 · Cochrane Headline outcomes onlyno estimate extracted1 study · 49 participantsVery low
Oral methotrexate plus intra‐articular glucocorticoid vs intra‐articular glucocorticoid alone
Withdrawals due to adverse events · children and young people with JIA
Oral methotrexate plus intra‐articular glucocorticoid showed no clear difference in withdrawals due to adverse events(12 months) compared with intra‐articular glucocorticoid alone (low certainty).
1 finding from 1 review
- RR 8.75 [0.48, 160.4]1 study · 207 participantsLow
Mepolizumab 10 mg/kg vs mepolizumab 0.55 mg/kg
Withdrawals due to adverse events · active EoE pediatric patients
It is very uncertain whether mepolizumab 10 mg/kg changes withdrawals due to adverse events at 8 weeks compared with mepolizumab 0.55 mg/kg (very low certainty).
1 finding from 1 review
- RR 0.63 [0.12, 3.38]1 study · 39 participantsVery low
Mepolizumab 2.5 mg/kg vs mepolizumab 0.55 mg/kg
Withdrawals due to adverse events · active EoE pediatric patients
It is very uncertain whether mepolizumab 2.5 mg/kg changes withdrawals due to adverse events at 8 weeks compared with mepolizumab 0.55 mg/kg (very low certainty).
1 finding from 1 review
- RR 0.32 [0.04, 2.79]1 study · 39 participantsVery low
Mepolizumab 10 mg/kg vs mepolizumab 2.5 mg/kg
Withdrawals due to adverse events · active EoE pediatric patients
It is very uncertain whether mepolizumab 10 mg/kg changes withdrawals due to adverse events at 8 weeks compared with mepolizumab 2.5 mg/kg (very low certainty).
1 finding from 1 review
- RR 2 [0.2, 20.33]1 study · 40 participantsVery low
Cromolyn sodium vs placebo
Withdrawals due to adverse events · active EoE pediatric patients
Cromolyn sodium showed no clear difference in withdrawals due to adverse events at 8 weeks compared with placebo (low certainty).
1 finding from 1 review
- RR 0.27 [0.01, 5.7]1 study · 16 participantsLow
Swallowed fluticasone vs prednisone
Withdrawals due to adverse events · active EoE pediatric patients
It is very uncertain whether swallowed fluticasone changes withdrawals due to adverse events at 4 weeks compared with oral prednisone (very low certainty).
1 finding from 1 review
- RR 0.5 [0.16, 1.53]1 study · 80 participantsVery low
Oral viscous budesonide vs swallowed fluticasone
Withdrawals due to adverse events · active EoE patients
Oral viscous budesonide showed no clear difference in withdrawals due to adverse events at 8 weeks compared with swallowed fluticasone (low certainty).
1 finding from 1 review
- RR 0.98 [0.42, 2.32]1 study · 129 participantsLow
Esomeprazole vs fluticasone
Withdrawals due to adverse events · active EoE patients
It is very uncertain whether esomeprazole changes withdrawals due to adverse events at 8 weeks compared with fluticasone (very low certainty).
1 finding from 1 review
- RR 0.95 [0.07, 13.38]2 studies · 72 participantsVery low
Four‐food elimination and amino acid formula vs four‐food elimination diet
Withdrawals due to adverse events · active EoE patients
It is very uncertain whether four‐food elimination and amino acid formula changes withdrawals due to adverse events at 6 weeks compared with four‐food elimination diet (very low certainty).
1 finding from 1 review
- RR 0.95 [0.06, 14.22]1 study · 41 participantsVery low