Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,337 questions · 1,354 findings · 566 reviews

No studies found 307 · 22.7%GRADE not reported 81 · 6%Very low 424 · 31.3%Low 310 · 22.9%Moderate 189 · 14%High 43 · 3.2%

Surgical interventions (exploration and decompression / external neurolysis, internal neurolysis, neurorrhaphy / direct repair, neuroma excision, anastomosis, autologous or allograft nerve grafting or tubulization) vs conservative interventions

Serious adverse events · Children and adolescents with femoral shaft fractures

Surgical interventions may leads to higher serious adverse events compared with conservative interventions (low certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events · neuropathic pain (5 studies in painful diabetic neuropathy and polyneuropathy)
1 finding from 1 review

Intervention not reported

Serious adverse events · neuropathic pain (6 studies in central neuropathic pain due to multiple sclerosis, spinal cord injury, polyneuropathy, central post‐stroke…
1 finding from 1 review

Intervention not reported

Serious adverse events · adults with peripheral neuropathic pain conditions
1 finding from 1 review

Intervention not reported

Serious adverse events · adults with neuropathic pain (3 studies in painful diabetic neuropathy and postherpetic neuralgia)
1 finding from 1 review

Intervention not reported

Serious adverse events · participants with rheumatoid arthritis and with partial response to MTX

The intervention showed no clear difference in serious adverse events (moderate certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events · participants with rheumatoid arthritis and with a partial response to DMARDs

The intervention showed no clear difference in serious adverse events (moderate certainty).

1 finding from 1 review

Fluoroquinolone substitution for ethambutol in a standard six month regimen vs standard regimen

Serious adverse events · Patients with presumed drug‐sensitive TB

It is very uncertain whether fluoroquinolone substitution for ethambutol in a standard six month… changes serious adverse events compared with standard regimen (very low certainty).

1 finding from 1 review

Fluoroquinolone substitution for isoniazid in a standard six month regimen vs standard regimen

Serious adverse events · Patients with presumed drug‐sensitive TB

Fluoroquinolone substitution for isoniazid in a standard six month… showed no clear difference in serious adverse events compared with standard regimen (low certainty).

1 finding from 1 review