What do systematic reviews say?

Exercise therapy plus antidepressants vs antidepressants alone

The review found no eligible studies for this question.

• Exercise therapy for chronic fatigue syndrome 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings: inhaled antioxidants vs placebo

• Antioxidant supplementation for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 153 participants
  Moderate

Summary of findings table ‐ Metformin + megestrol vs megestrol

The review found no eligible studies for this question.

• Metformin for endometrial hyperplasia 2024 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Metformin vs megestrol

The review found no eligible studies for this question.

• Metformin for endometrial hyperplasia 2024 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Exercise vs no exercise

• Exercise‐based cardiac rehabilitation in heart transplant recipients 2017 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 120 participants
  Moderate

Silver diamine fluoride (SDF) vs placebo

SDF did not significantly differ from placebo for oral health-related quality of life in children (MD 0.03, 95% CI -0.16 to 0.22; ungraded).

• Silver diamine fluoride and oral health-related quality of life: A review and network meta-analysis. 2022 All outcomes

  Post-treatment · Pediatric dental care; trials conducted in China, the USA, and Brazil
  MD 0.03 [-0.16, 0.22]
  2 studies · 440 participants
  GRADE not reported

Silver diamine fluoride (SDF) vs Atraumatic restorative treatment (ART)

SDF did not significantly differ from atraumatic restorative treatment for oral health-related quality of life (MD 0.02, 95% CI -0.32 to 0.36; ungraded).

• Silver diamine fluoride and oral health-related quality of life: A review and network meta-analysis. 2022 All outcomes

  Post-treatment · Pediatric dental care; trials conducted in China, the USA, and Brazil
  MD 0.02 [-0.32, 0.36]
  2 studies · 134 participants
  GRADE not reported

Silver diamine fluoride (SDF) plus fluoride varnish vs Atraumatic restorative treatment + fluoride varnish (ART+FV)

SDF plus fluoride varnish did not significantly differ from ART plus fluoride varnish for oral health-related quality of life (MD 0.16, 95% CI -0.1 to 0.42; ungraded).

• Silver diamine fluoride and oral health-related quality of life: A review and network meta-analysis. 2022 All outcomes

  Post-treatment · Pediatric dental care; trials conducted in China, the USA, and Brazil
  MD 0.16 [-0.1, 0.42]
  1 study · 246 participants
  GRADE not reported

Psychological therapies vs education

• Psychological therapies for the treatment of depression in chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 460 participants
  Very low

Summary of findings: levodopa vs other dopamine agonists

• Levodopa for the treatment of restless legs syndrome 2011 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 314 participants
  Moderate

Dopamine agonist vs levodopa

• Dopamine agonists for the treatment of restless legs syndrome 2011 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 314 participants
  Moderate

Counselling vs usual care

The review found no eligible studies for this question.

• Psychosocial interventions for preventing and treating depression in dialysis patients 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Serenoa repens vs placebo or no intervention

Serenoa repens showed no clear difference in quality of lifeMeasured by IPSS‐QoL score (range 0 to 6) compared with placebo or no intervention (high certainty).

• Serenoa repens for the treatment of lower urinary tract symptoms due to benign prostatic enlargement 2023 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 1001 participants
  High

Serenoa repens in combination with other phytotherapy vs placebo or no intervention

• Serenoa repens for the treatment of lower urinary tract symptoms due to benign prostatic enlargement 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 265 participants
  Very low

Psychotherapy preceded by motivational interviewing vs psychotherapy alone

• Psychosocial interventions for conversion and dissociative disorders in adults 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 47 participants
  Very low

Surgery vs Pharmacological therapy

Surgery alone showed no clear difference in health‐related quality of life Mean AcroQoL score (0‐100) compared with pharmacological therapy alone (low certainty).

• Surgical and non‐surgical interventions for primary and salvage treatment of growth hormone‐secreting pituitary… 2024 · Cochrane Headline outcomes only
  MD 10
  1 study · 22 participants
  Low

Cognitive behavioural therapy as vs standard‐of‐care therapy

• Psychosocial interventions for conversion and dissociative disorders in adults 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 16 participants
  Very low

Lateral wedge insole vs neutral insole

• Braces and orthoses for treating osteoarthritis of the knee 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 179 participants
  Moderate

Summary of findings table ‐ Systemic therapy vs control

• Systemic therapies for preventing or treating aromatase inhibitor‐induced musculoskeletal symptoms in early breast… 2022 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 147 participants
  Very low

Summary of findings table ‐ Systemic therapy vs control

• Systemic therapies for preventing or treating aromatase inhibitor‐induced musculoskeletal symptoms in early breast… 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 44 participants
  Low