What do systematic reviews say?

FAE vs MTX

• Oral fumaric acid esters for psoriasis 2015 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Tonsillectomy or adenotonsillectomy vs no surgery

• Tonsillectomy or adenotonsillectomy versus non‐surgical treatment for chronic/recurrent acute tonsillitis 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 2 participants
  Low

Intervention not reported

• Aminoadamantanes for chronic hepatitis C 2014 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 1181 participants
  Very low

Commercial mouthcare system (Biotene Oral Balance / Xerostom) vs Usual care or CMC-based control

• Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
  Ship 2007 reported xerostomia-related quality of life; no usable comparative data.
  1 study
  GRADE not reported

Commercial mouthcare system (Biotene Oral Balance / Xerostom) vs Bioxtra mouthcare system

• Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
  No difference between systems for overall xerostomia-related quality of life (15-item survey). Bioxtra rated better for taste; no difference for mouth 'feel'. Trial likely underpowered.
  1 study · 20 participants
  GRADE not reported

Guided tissue regeneration (GTR) with barrier membrane (resorbable or non-resorbable) vs Open flap debridement (access flap surgery)

• Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes
  Cortellini 2001: 36% of GTR patients reported the procedure interfered with daily activity for an average of 2.7 days versus 32% of controls for an average of 2.4 days; no significant difference for postoperative pain…
  1 study
  GRADE not reported

Pharmacological interventions vs pharmacological intervention

The review found no eligible studies for this question.

• Pharmacological and non‐pharmacological strategies for obese women with subfertility 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Pharmacological interventions vs placebo or no intervention

The review found no eligible studies for this question.

• Pharmacological and non‐pharmacological strategies for obese women with subfertility 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Non‐pharmaceutical interventions vs placebo or no intervention

The review found no eligible studies for this question.

• Pharmacological and non‐pharmacological strategies for obese women with subfertility 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

VIDEO GAMES (EXERGAMES) (plus standard care) vs usual care

• Video games for people with schizophrenia 2021 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

VIDEO GAMES (EXERGAMES) (plus standard care) vs VIDEO GAMES (NON‐EXERGAMES) (plus standard care)

• Video games for people with schizophrenia 2021 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Telerehabilitation vs no rehabilitation control

Telerehabilitation showed no clear difference in quality of life ‐ CRQ dyspnoea domain compared with no rehabilitation control (low certainty).

• Telerehabilitation for chronic respiratory disease 2021 · Cochrane Headline outcomes only
  MD 1.97
  2 studies · 94 participants
  Low

NOAC (rivaroxaban) vs vitamin K antagonist (VKA)

• Antiplatelet and anticoagulant agents for secondary prevention of stroke and other thromboembolic events in people… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 111 participants
  Low

CBT vs audiological care (tinnitus education and rehabilitation

• Cognitive behavioural therapy for tinnitus 2020 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 430 participants
  Moderate

CBT vs TRT (directive counselling and bilateral masking)

• Cognitive behavioural therapy for tinnitus 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 42 participants
  Low

Summary of findings: Iron vs placebo

It is very uncertain whether iron changes quality of life (dichotomous measure) compared with placebo (very low certainty).

• Iron for the treatment of restless legs syndrome 2019 · Cochrane Headline outcomes only
  RR 2.01 [0.54, 7.45]
  2 studies · 39 participants
  Very low

Sulphasalazine vs placebo

The review found no eligible studies for this question.

• Oral 5‐aminosalicylic acid for maintenance of surgically‐induced remission in Crohn's disease 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Augmentation of current antidepressant (SSRI/SNRI) with mirtazapine (30 mg/d) vs augmentation of current antidepressant (various) with placebo

• Pharmacological interventions for treatment‐resistant depression in adults 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 447 participants
  High

Exposure to pulsed magnetic fields (in addition to self‐care and protective footwear) vs self‐care and footwear

The review found no eligible studies for this question.

• Interventions for ulceration and other skin changes caused by nerve damage in leprosy 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Prostanoids vs lumbar sympathectomy

The review found no eligible studies for this question.

• Lumbar sympathectomy versus prostanoids for critical limb ischaemia due to non‐reconstructable peripheral arterial… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found