What do systematic reviews say?

Fixed‐dose combination aclidinium/formoterol vs formoterol

Fixed‐dose combination aclidinium/formoterol showed no clear difference in quality of life: number of participants with clinically significant… compared with formoterol (low certainty).

• Combined aclidinium bromide and long‐acting beta2‐agonist for chronic obstructive pulmonary disease (COPD) 2018 · Cochrane Headline outcomes only
  OR 1.15 [0.89, 1.5]
  1 study · 1000 participants
  Low

Intervention not reported

• Stretch for the treatment and prevention of contractures 2017 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 97 participants
  Moderate

Corticosteroids vs placebo

The review found no eligible studies for this question.

• Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Reablement vs usual home‐care

• Time‐limited home‐care reablement services for maintaining and improving the functional independence of older adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 249 participants
  Very low

Amantadine vs placebo

The review found no eligible studies for this question.

• Interventions for fatigue in peripheral neuropathy 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Benralizumab 10 mg vs placebo

• Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 680 participants
  Moderate

Benralizumab 30 mg vs placebo

• Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 1333 participants
  Moderate

Benralizumab 100 mg vs placebo

• Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 1351 participants
  High

Surgical vs conservative interventions

• Surgical versus conservative interventions for treating fractures of the middle third of the clavicle 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 321 participants
  Low

PFMT added to bladder training vs bladder training alone

• Pelvic floor muscle training added to another active treatment versus the same active treatment alone for urinary… 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 118 participants
  Very low

Day hospitals vs Inpatient

• Day hospital versus admission for acute psychiatric disorders 2011 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 1117 participants
  Moderate

Antidepressants vs placebo

Antidepressant probably leads to higher quality of life (EuroQol, scale −0.11 to 1.0 where a score of 1.0… compared with placebo (moderate certainty).

• Antidepressants for hip and knee osteoarthritis 2022 · Cochrane Headline outcomes only
  MD 0.04 [0.01, 0.07]
  3 studies · 815 participants
  Moderate

Self‐management interventions vs usual care

Self management programmes showed no clear difference in quality of life Change scores/post intervention SF‐12 or ‐36:… compared with usual care (low certainty).

• Self management programmes for quality of life in people with stroke 2016 · Cochrane Headline outcomes only
  SMD 0.2 [0, 0.41]
  6 studies · 469 participants
  Low

Non‐invasive ventilation during exercise training vs exercise training alone or exercise training with sham non‐invasive ventilation

• Non‐invasive ventilation during exercise training for people with chronic obstructive pulmonary disease 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 48 participants
  Moderate

Exercise vs no exercise

• Exercise interventions for adults with cancer receiving radiation therapy alone 2023 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 112 participants
  Low

Antihypertensive drug therapy vs placebo

• Pharmacological treatment of hypertension in people without prior cerebrovascular disease for the prevention of… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 15795 participants
  Very low

Mepolizumab 300 mg vs placebo

• Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 451 participants
  Moderate

Mepolizumab 100 mg vs placebo

• Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 911 participants
  Moderate

Mucolytic vs placebo

• Mucolytic agents versus placebo for chronic bronchitis or chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 2721 participants
  Moderate

Intervention not reported

• Adalimumab for induction of remission in Crohn's disease 2019 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 714 participants
  Moderate