Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,241 questions · 3,336 findings · 1,340 reviews

No studies found 1,581 · 47.4%GRADE not reported 352 · 10.6%Very low 512 · 15.3%Low 509 · 15.3%Moderate 316 · 9.5%High 66 · 2%

Amifostine vs no treatment/placebo

Quality of life (Patient Benefit Questionnaire, 10-point scale) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region

It is very uncertain whether amifostine changes quality of life (Patient Benefit Questionnaire, 10-point scale) compared with no treatment/placebo (very low certainty).

1 finding from 1 review

Subacute to Chronic WAD: Trunk/Extremity Stretch/ROM + Trunk/Extremity Strengthening + Trunk/Extremity Endurance Training + Pattern/Synchronization: Coordination + Cardiovascular/Aerobic + Cognitive (CBT) + ANOTHER TREATMENT vs THAT SAME OTHER TREATMENT

QoL · patients with subacute/chronic WAD

Subacute to Chronic WAD: Trunk/Extremity Stretch/ROM +… showed no clear difference in quality of Life: SF‐36 0 high disability to 100 no disability ( compared with THAT SAME OTHER TREATMENT (low certainty).

1 finding from 1 review