What do systematic reviews say?

Combination of manual therapy, exercise, electrotherapy and glucocorticoid injection vs glucocorticoid injection

• Manual therapy and exercise for adhesive capsulitis (frozen shoulder) 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 44 participants
  Low

Combination of manual therapy and exercise following joint distension vs sham ultrasound following joint distension

• Manual therapy and exercise for adhesive capsulitis (frozen shoulder) 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 148 participants
  High

Summary of findings: percutaneous pinning vs cast or brace immobilisation only

• Percutaneous pinning for treating distal radial fractures in adults 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 54 participants
  Very low

Exercise vs control

• Exercise interventions for adults after liver transplantation 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 169 participants
  Very low

Tocilizumab weekly vs placebo + 52‐week taper

Tocilizumab weekly probably leads to higher mean change in quality of life at ≥ 12 months using the 36‐Item… compared with placebo + 52‐week taper (moderate certainty).

• Tocilizumab for giant cell arteritis 2022 · Cochrane Headline outcomes only
  MD 8.18 [4.44, 11.9]
  1 study · 77 participants
  Moderate

Tocilizumab weekly vs placebo + 26‐week taper

Tocilizumab weekly showed no clear difference in mean change in quality of life at ≥ 12 months using the 36‐Item… compared with placebo + 26‐week taper (moderate certainty).

• Tocilizumab for giant cell arteritis 2022 · Cochrane Headline outcomes only
  MD 3.29
  1 study · 68 participants
  Moderate

Tocilizumab every other week vs placebo + 52‐week taper

Tocilizumab every other week probably leads to higher mean change in quality of life at ≥ 12 months using the 36‐Item… compared with placebo + 52‐week taper (moderate certainty).

• Tocilizumab for giant cell arteritis 2022 · Cochrane Headline outcomes only
  MD 5.51 [0.82, 10.2]
  1 study · 44 participants
  Moderate

Tocilizumab every other week vs placebo + 26‐week taper

Tocilizumab every other week showed no clear difference in mean change in quality of life at ≥ 12 months using the 36‐Item… compared with placebo + 26‐week taper (moderate certainty).

• Tocilizumab for giant cell arteritis 2022 · Cochrane Headline outcomes only
  MD 0.63
  1 study · 35 participants
  Moderate

Tocilizumab every 4 weeks vs placebo

The review found no eligible studies for this question.

• Tocilizumab for giant cell arteritis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Acupuncture as an addition to the routine primary care that trial participants were receiving from their physicians vs routine primary physician care alone

• Acupuncture for hip osteoarthritis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 137 participants
  Low

Acupuncture as an addition to the routine primary care that trial participants were receiving from their physicians vs routine primary physician care alone

• Acupuncture for hip osteoarthritis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 137 participants
  Low

Surgical vs non‐surgical treatment

• Surgical versus non‐surgical interventions for displaced intra‐articular calcaneal fractures 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 192 participants
  Low

Preoperative education vs usual care

• Preoperative education for hip or knee replacement 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 109 participants
  Low

Intervention not reported

• Surgical versus conservative interventions for treating anterior cruciate ligament injuries 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 121 participants
  Low

Anterior vs posterior surgical approaches

• Surgical approaches for cervical spine facet dislocations in adults 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 33 participants
  Very low

Surgical interventions (exploration and decompression / external neurolysis, internal neurolysis, neurorrhaphy / direct repair, neuroma excision, anastomosis, autologous or allograft nerve grafting or tubulization) vs conservative interventions

• Surgical versus conservative interventions for treating acromioclavicular dislocation of the shoulder in adults 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 122 participants
  Low

Home‐based exercise therapy vs walking advice

• Supervised exercise therapy versus home‐based exercise therapy versus walking advice for intermittent claudication 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 20 participants
  Very low

Supervised exercise therapy vs home exercises

• Supervised exercise therapy versus home‐based exercise therapy versus walking advice for intermittent claudication 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 68 participants
  Low

Supervised exercise therapy vs walking advice

• Supervised exercise therapy versus home‐based exercise therapy versus walking advice for intermittent claudication 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 296 participants
  Low

Diflunisal vs placebo

• Pharmacological treatment for familial amyloid polyneuropathy 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 130 participants
  Very low