What do systematic reviews say?

Amoxicillin + clavulanate + SRP vs SRP

The review found no eligible studies for this question.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  Included studies have not reported this outcome
  Studies not reported
  No studies found

Clindamycin + SRP vs Doxycycline + SRP

The review found no eligible studies for this question.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  Included studies have not reported this outcome
  Studies not reported
  No studies found

Azithromycin + SRP vs SRP

The review found no eligible studies for this question.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  Included studies have not reported this outcome
  Studies not reported
  No studies found

Metronidazole + SRP vs SRP

The review found no eligible studies for this question.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  Included studies have not reported this outcome
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Compression therapy for treating post‐thrombotic syndrome 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

• Compression therapy for treating post‐thrombotic syndrome 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 32 participants
  Moderate

Intervention not reported

The review found no eligible studies for this question.

• Dressings and topical agents for arterial leg ulcers 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Steroids vs lubricants

The review found no eligible studies for this question.

• Topical corticosteroids for dry eye 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Steroids vs cyclosporine A

The review found no eligible studies for this question.

• Topical corticosteroids for dry eye 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Chlorhexidine gel (0.12%) vs no treatment

The review found no eligible studies for this question.

• Chlorhexidine treatment for the prevention of dental caries in children and adolescents 2015 · Cochrane All outcomes
  Neither of these trials reported on the other secondary outcomes such as measures of pain, quality of life, patient satisfaction or direct and indirect costs of interventions.
  0 studies
  No studies found

Chlorhexidine varnish vs placebo or no treatment

The review found no eligible studies for this question.

• Chlorhexidine treatment for the prevention of dental caries in children and adolescents 2015 · Cochrane All outcomes
  No trials reported on pain, quality of life, patient satisfaction or costs.
  0 studies
  No studies found

Supportive interventions for enhancing dietary intake vs comparators

• Supportive interventions for enhancing dietary intake in malnourished or nutritionally at‐risk adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 4451 participants
  Low

Ball (stud) attachment system vs Bar attachment system

• Interventions for replacing missing teeth: attachment systems for implant overdentures in edentulous jaws 2018 · Cochrane All outcomes
  Only Walton 2002 assessed patient satisfaction but reported narrative results and failed to provide any usable numbers. Quality of life as assessed by a validated measure was not recorded in any of the trials.
  1 study
  GRADE not reported

Ball (stud) attachment system vs Telescopic attachment system

• Interventions for replacing missing teeth: attachment systems for implant overdentures in edentulous jaws 2018 · Cochrane All outcomes
  Cepa 2017 assessed patient satisfaction but did not use validated measures and we could not use the data. Quality of life as assessed by a validated measure was not recorded.
  1 study
  GRADE not reported

Ball (stud) attachment system vs Magnetic attachment system

• Interventions for replacing missing teeth: attachment systems for implant overdentures in edentulous jaws 2018 · Cochrane All outcomes
  Two trials (Cune 2010; Naert 1999) reported patient satisfaction. However, we could not use any data from these studies. Quality of life as assessed by a validated measure was not recorded in any of the trials.
  2 studies
  GRADE not reported

Amifostine vs no treatment/placebo

It is very uncertain whether amifostine changes quality of life (Patient Benefit Questionnaire, 10-point scale) compared with no treatment/placebo (very low certainty).

• Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes

  12 months postRT
  MD 0.70 [0.20, 1.20]
  1 study · 180 participants
  Very low

Single full-coverage metal-ceramic crown over composite core and post vs Direct adhesive composite restoration with post (conventional filling, no crown)

The review found no eligible studies for this question.

• Single crowns versus conventional fillings for the restoration of root‐filled teeth 2015 · Cochrane All outcomes
  This outcome was not reported nor measured by the study. The abstract confirms no evidence was available for any secondary outcome.
  Studies not reported
  No studies found

Personalised one-to-one OHA vs Routine one-to-one OHA

• One‐to‐one oral hygiene advice provided in a dental setting for oral health 2018 · Cochrane All outcomes
  Jonsson 2009 (OHQoL-UK oral health-related quality of life) and Ramsay 2018 (dental quality of life, oral hygiene self-efficacy); measured, not synthesised or GRADE-rated.
  2 studies
  GRADE not reported

Any form of one-to-one oral hygiene advice (OHA) vs No OHA

• One‐to‐one oral hygiene advice provided in a dental setting for oral health 2018 · Cochrane All outcomes
  Hoogstraten 1983 (dental knowledge, attitude, behaviour, fear of dental treatment) and Memarpour 2016 (parents' knowledge and performance regarding oral health); measured, not synthesised or GRADE-rated.
  2 studies
  GRADE not reported

Enhanced one-to-one OHA vs Routine one-to-one OHA

• One‐to‐one oral hygiene advice provided in a dental setting for oral health 2018 · Cochrane All outcomes
  Hoogstraten 1983 (dental knowledge, attitude, behaviour, fear), Munster Halvari 2012 (multiple psychological measures: autonomy, motivation, perceived competence), Tedesco 1992 (theory of reasoned action variables);…
  3 studies
  GRADE not reported