Findings

What do systematic reviews say?

6 questions · 6 findings · 4 reviews · Gynaecology and Fertility

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No studies found 1 · 16.7%GRADE not reported 0 · 0%Very low 4 · 66.7%Low 0 · 0%Moderate 1 · 16.7%High 0 · 0%

IVF vs unstimulated IUI

Miscarriage · women with unexplained subfertility

It is very uncertain whether IVF changes miscarriage rate per woman randomised compared with unstimulated IUI (very low certainty).

1 finding from 1 review

In vitro fertilisation for unexplained subfertility 2023 · Cochrane Headline outcomes only
OR 1.72 [0.14, 21.25]
1 study · 43 participants
Very low

IVF vs IUI + ovarian stimulation with gonadotropins or CC

Miscarriage · women with unexplained subfertility

It is very uncertain whether IVF changes miscarriage rate per woman randomised compared with IUI + ovarian stimulation with gonadotropins or CC (very low certainty).

1 finding from 1 review

In vitro fertilisation for unexplained subfertility 2023 · Cochrane Headline outcomes only
OR 0.31 [0.03, 3.04]
1 study · 207 participants
Very low

IVF vs expectant management

Miscarriage · women with unexplained subfertility

The review found no eligible studies for this question.

1 finding from 1 review

In vitro fertilisation for unexplained subfertility 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Assisted hatching vs no assisted hatching

Miscarriage · women undergoing assisted reproduction

It is very uncertain whether assisted hatching changes miscarriage rate per woman randomised compared with no assisted hatching (very low certainty).

1 finding from 1 review

Assisted hatching on assisted conception (in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI)) 2021 · Cochrane Headline outcomes only
OR 1.13 [0.82, 1.56]
17 studies · 2810 participants
Very low

G‐CSF vs no treatment or placebo

Miscarriage · Subfertile women undergoing assisted reproduction

It is very uncertain whether G‐CSF changes miscarriage rate per woman randomised compared with no treatment or placebo (very low certainty).

1 finding from 1 review

Granulocyte‐colony stimulating factor administration for subfertile women undergoing assisted reproduction 2020 · Cochrane Headline outcomes only
Peto OR 0.4 [0.09, 1.77]
2 studies · 291 participants
Very low

GnRH antagonist vs long‐course GnRH agonist

Miscarriage · women undergoing assisted reproductive technology (ART)

GnRH antagonist showed no clear difference in miscarriage rate per woman randomised compared with long‐course GnRH agonist (moderate certainty).

1 finding from 1 review

Gonadotrophin‐releasing hormone antagonists for assisted reproductive technology 2016 · Cochrane Headline outcomes only
OR 1.03 [0.82, 1.29]
34 studies · 7082 participants
Moderate