Findings

What do systematic reviews say?

7 questions · 8 findings · 5 reviews · Gynaecology and Fertility

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No studies found 1 · 12.5%GRADE not reported 0 · 0%Very low 2 · 25%Low 3 · 37.5%Moderate 2 · 25%High 0 · 0%

Embryo culture supernatant injection vs no intervention

Live birth or ongoing pregnancy · Subfertile women undergoing assisted reproduction

It is very uncertain whether embryo culture supernatant injection changes live birth/ongoing pregnancy compared with no intervention (very low certainty).

1 finding from 1 review

Endometrial injection of embryo culture supernatant for subfertile women in assisted reproduction 2020 · Cochrane Headline outcomes only
OR 1.11 [0.73, 1.7]
3 studies · 340 participants
Very low

Embryo culture supernatant vs culture medium injection

Live birth or ongoing pregnancy · Subfertile women undergoing assisted reproduction

The review found no eligible studies for this question.

1 finding from 1 review

Endometrial injection of embryo culture supernatant for subfertile women in assisted reproduction 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Progesterone vs no treatment or placebo (route of progesterone administration)

Live birth or ongoing pregnancy · women trying to conceive by intrauterine insemination

Progesterone showed no clear difference in live birth/ongoing pregnancy rate compared with no treatment or placebo (route of progesterone administration) (low certainty).

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
RR 1.1 [0.81, 1.48]
7 studies · 1792 participants
Low

DHEA or testosterone vs placebo/no treatment

Live birth or ongoing pregnancy · women undergoing assisted reproduction

DHEA or testosterone probably leads to higher live birth/ongoing pregnancy rate ‐ DHEA compared with placebo/no treatment (moderate certainty).

2 findings from 1 review

Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction 2015 · Cochrane Headline outcomes only
OR 1.81 [1.25, 2.62]
8 studies · 878 participants
Moderate
Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction 2015 · Cochrane Headline outcomes only
OR 2.6 [1.3, 5.2]
4 studies · 345 participants
Moderate

Intervention not reported

Live birth/ongoing pregnancy ‐ short vs long protocol · subfertile women

The intervention showed no clear difference in live birth/ongoing pregnancy ‐ short vs long protocol (low certainty).

1 finding from 1 review

Luteal phase support for assisted reproduction cycles 2015 · Cochrane Headline outcomes only
OR 1.08 [0.81, 1.43]
1 study · 910 participants
Low

Intervention not reported

Live birth/ongoing pregnancy ‐ low vs high dose protocol · subfertile women

It is very uncertain whether the intervention changes live birth/ongoing pregnancy ‐ low vs high dose protocol (very low certainty).

1 finding from 1 review

Luteal phase support for assisted reproduction cycles 2015 · Cochrane Headline outcomes only
OR 0.65 [0.37, 1.13]
1 study · 285 participants
Very low

GnRHa depot vs GnRHa daily injection

Ongoing pregnancy / live birth rate per woman · women undergoing pituitary suppression in assisted reproduction

GnRHa depot showed no clear difference in live birth/ongoing pregnancy rate per woman Delivery of one or more… compared with gnRHa daily injection (low certainty).

1 finding from 1 review

Depot versus daily administration of gonadotrophin‐releasing hormone agonist protocols for pituitary down regulation… 2013 · Cochrane Headline outcomes only
OR 0.95 [0.7, 1.31]
7 studies · 873 participants
Low