Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

17 questions · 17 findings · 4 reviews · Skin

No studies found 3 · 17.6%GRADE not reported 0 · 0%Very low 2 · 11.8%Low 5 · 29.4%Moderate 6 · 35.3%High 1 · 5.9%

Acyclovir vs placebo, vitamins, or no treatment

Minor adverse events not leading to withdrawal of treatment · pityriasis rosea

Acyclovir showed no clear difference in minor participant‐reported adverse events not requiring withdrawal… compared with placebo, vitamins, or no treatment (moderate certainty).

1 finding from 1 review

Clarithromycin vs placebo

Minor adverse events not leading to withdrawal of treatment · pityriasis rosea

The review found no eligible studies for this question.

1 finding from 1 review

Acyclovir + calamine + cetirizine vs calamine + cetirizine

Minor participant‐reported adverse events not requiring withdrawal of the treatment: Headache. · pityriasis rosea

Acyclovir + calamine + cetirizine showed no clear difference in minor participant‐reported adverse events not requiring withdrawal… compared with calamine + cetirizine (low certainty).

1 finding from 1 review

Azithromycin vs placebo or vitamins

Minor participant‐reported adverse events not requiring withdrawal of the treatment: Mild abdominal pain. · pityriasis rosea

Azithromycin showed no clear difference in minor participant‐reported adverse events not requiring withdrawal… compared with placebo or vitamins (moderate certainty).

1 finding from 1 review

Erythromycin vs placebo

Adverse events: minor gastrointestinal symptoms · pityriasis rosea

Erythromycin showed no clear difference in minor participant‐reported adverse events not requiring withdrawal… compared with placebo (moderate certainty).

1 finding from 1 review

P‐3051 (ciclopirox 8% hydrolacquer) vs comparators

Adverse events (collected over the course of the studies; they are not measured/reported for specific time points) · People with fungal infections of the toenails

P‐3051 (ciclopirox 8% hydrolacquer) showed no clear difference in adverse events (collected over the course of the studies; they are… compared with comparators (low certainty).

1 finding from 1 review

Nd:YAG laser vs no treatment/sham

Adverse events (collected over the course of the studies; they are not measured/reported for specific time points) · People with fungal infections of the toenails

It is very uncertain whether 1064‐nm Nd:YAG laser changes adverse events (collected over the course of the studies; they are… compared with no treatment or sham treatment (very low certainty).

1 finding from 1 review

Luliconazole 5% solution vs vehicle

Adverse events (collected over the course of the studies; they are not measured/reported for specific time points) · People with fungal infections of the toenails

Luliconazole 5% solution showed no clear difference in adverse events (collected over the course of the studies; they are… compared with vehicle (low certainty).

1 finding from 1 review

Efinaconazole 10% solution vs vehicle

Adverse events (collected over the course of the studies; they are not measured/reported for specific time points) · People with fungal infections of the toenails

Efinaconazole 10% solution leads to higher adverse events (collected over the course of the studies; they are… compared with vehicle (high certainty).

1 finding from 1 review

Tavaborole 5% solution vs vehicle

Adverse events (directly related to treatment, collected over the course of the studies; they are not measured/reported for specific time points) · People with fungal infections of the toenails

Tavaborole 5% solution probably leads to higher adverse events (directly related to treatment, collected over the… compared with vehicle (moderate certainty).

1 finding from 1 review

Ciclopirox 8% lacquer vs vehicle

Adverse events (directly related to treatment, collected over the course of the studies; they are not measured/reported for specific time points) · People with fungal infections of the toenails

Ciclopirox 8% lacquer showed no clear difference in adverse events (directly related to treatment, collected over the… compared with vehicle (low certainty).

1 finding from 1 review