Probiotics vs placebo
Probiotics showed no clear difference in adverse events (serious adverse reaction and adverse reaction) compared with placebo (low certainty).
- RR 3 [0.49, 18.46]5 studies · 310 participantsLow
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Probiotics showed no clear difference in adverse events (serious adverse reaction and adverse reaction) compared with placebo (low certainty).
The review found no eligible studies for this question.
It is very uncertain whether tramadol alone changes number of participants experiencing any serious adverse events compared with NSAIDs (very low certainty).
It is very uncertain whether tramadol alone changes number of participants experiencing any serious adverse events compared with other opioids (very low certainty).
The review found no eligible studies for this question.
Tramadol alone may leads to higher number of participants experiencing any serious adverse events compared with placebo (low certainty).
Losigamone showed no clear difference in the proportion of participants experiencing any adverse events compared with placebo (moderate certainty).
It is very uncertain whether oestrogen in combination with progestogen (sequential or continuous) changes withdrawal due to adverse events over 2 to 4 menstrual cycles1 compared with placebo (very low certainty).
It is very uncertain whether abrupt discontinuation deprescribing changes adverse drug withdrawal events ‐ relapse (endoscopic findings) compared with continued use (very low certainty).
It is very uncertain whether lidocaine changes adverse events (AEs; adverse drug reaction): any adverse event compared with tocainide (very low certainty).
It is very uncertain whether lidocaine changes adverse events (AEs; adverse drug reaction): sinus bradycardia compared with placebo or no intervention (very low certainty).
Nicotine EC showed no clear difference in adverse events at 4 weeks to 6‐9 months Assessed by self‐report compared with NRT (moderate certainty).
Nicotine EC may leads to higher adverse events at 12 weeks to 6 months Assessed via self‐report compared with behavioural support only/no support (low certainty).
Summary of findings table ‐ Daratumumab plus standard therapy probably leads to higher adverse events: infections (CTCAE grade ≥ 3) (longest available compared with standard therapy (moderate certainty).