Tramadol vs placebo: Number of participants experiencing any serious adverse events
- Population
- Patients with osteoarthritis of the knee or hip
- Intervention
- Tramadol
- Comparison
- placebo
- Outcome
- Number of participants experiencing any serious adverse events
Tramadol alone may leads to higher number of participants experiencing any serious adverse events compared with placebo (low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Tramadol alone vs placebo Number of participants experiencing any serious adverse events · osteoarthritis of the hip or knee, or both Tramadol alone may leads to higher number of participants experiencing any serious adverse events compared with placebo (low certainty). Tramadol for osteoarthritis (2019) · Cochrane Headline outcomes only | RR 1.78 [1.11, 2.84] | 7 studies · 3612 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Tramadol for osteoarthritis 2019 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Tramadol vs other opioids · patients with osteoarthritis · 1 review
- Tramadol vs NSAIDs · patients with osteoarthritis · 1 review
- Tramadol vs paracetamol · patients with osteoarthritis · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.