Cochrane · systematic review · CD010643
Hyaluronic acid and other conservative treatment options for osteoarthritis of the ankle
Witteveen, AGH, Hofstad, CJ, Kerkhoffs, GMMJ · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
MusculoskeletalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
2
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 4 · 66.7%Very low 0 · 0%Low 2 · 33.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Hyaluronic acid for osteoarthritis of the ankle
Population: patients with osteoarthritis of the ankle
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
AOS total (Pain & Physical function) AOS total score. Scale from: 0 to 100 (0 = being no pain/disability, 100 = worst imaginable pain/disability). | no estimate extracted | 2 studies · 45 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Radiographic Joint Structure Changes | no estimate extracted | 0 studies · 0 participants | Ungraded |
Quality of Life SF12. Scale from: 0 to 100. | no estimate extracted | 2 studies · 45 participants | Ungraded |
Number of participants experiencing any serious adverse events | no estimate extracted | 3 studies · 109 participants | Ungraded |
Number of participants experiencing any adverse event | RR 1.66 [0.47, 5.88] | 3 studies · 109 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Participants who withdraw because of an adverse event or any other reason | no estimate extracted | 3 studies · 109 participants | Ungraded |