Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,918 questions · 5,537 findings · 1,803 reviews

No studies found 1,309 · 23.6%GRADE not reported 440 · 7.9%Very low 1,560 · 28.2%Low 1,292 · 23.3%Moderate 751 · 13.6%High 185 · 3.3%

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Celecoxib vs tNSAIDs

Number of participants experiencing any serious adverse events · patients with osteoarthritis

It is very uncertain whether celecoxib changes number experiencing any serious adverse events compared with tNSAIDs (very low certainty).

1 finding from 1 review

Celecoxib vs placebo

Number of participants experiencing any serious adverse events · patients with osteoarthritis

It is very uncertain whether celecoxib changes number experiencing any serious adverse events compared with placebo (very low certainty).

1 finding from 1 review

Lactulose vs lactitol

Non‐serious adverse events (secondary outcome) · prevention and treatment of hepatic encephalopathy in people with cirrhosis

It is very uncertain whether lactulose changes non‐serious adverse events (secondary outcome) compared with lactitol (very low certainty).

1 finding from 1 review

Non‐absorbable disaccharides vs placebo or no intervention

Non‐serious adverse events (secondary outcome) · prevention and treatment of hepatic encephalopathy in people with cirrhosis

It is very uncertain whether non‐absorbable disaccharides changes non‐serious adverse events (secondary outcome) compared with placebo/no intervention (very low certainty).

1 finding from 1 review

Botulinum neurotoxin B vs placebo

Proportion of participants with adverse events · adults with cervical dystonia

It is very uncertain whether botulinum neurotoxin B changes proportion of participants with adverse events compared with placebo (very low certainty).

1 finding from 1 review

Pre‐hospital cooling vs in‐hospital cooling

Adverse events ‐ re‐arrest after randomization · patients with out‐of‐hospital cardiac arrest

It is very uncertain whether pre‐hospital cooling changes adverse events ‐ re‐arrest after randomization compared with in‐hospital cooling (very low certainty).

1 finding from 1 review

Infliximab combined with purine analogues vs purine analogues

Serious adverse events (at 48 weeks to 2 years) · Participants with Crohn's disease in remission

It is very uncertain whether infliximab combined with purine analogues changes serious adverse events (at 48 weeks to 2 years) compared with purine analogues (very low certainty).

1 finding from 1 review

Helium vs carbon dioxide

Pneumoperitoneum‐related serious adverse events · people undergoing laparoscopic general abdominal or gynaecological pelvic surgery under general anaesthesia

It is very uncertain whether helium changes pneumoperitoneum‐related serious adverse events compared with carbon dioxide (very low certainty).

1 finding from 1 review

Clonidine and opioid vs opioid

Adverse events (treatment related) To discharge · newborn infants with opioid withdrawal

It is very uncertain whether clonidine and opioid changes adverse events (treatment related) To discharge compared with opioid alone (very low certainty).

1 finding from 1 review

Morphine vs methadone

Adverse events (treatment related) To discharge · newborn infants with opioid withdrawal

Morphine showed no clear difference in adverse events (treatment related) To discharge compared with methadone (low certainty).

1 finding from 1 review

Morphine vs buprenorphine

Adverse events (treatment related) To discharge · newborn infants with opioid withdrawal

It is very uncertain whether morphine changes adverse events (treatment‐related) To discharge compared with buprenorphine (very low certainty).

1 finding from 1 review