Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,918 questions · 5,537 findings · 1,803 reviews

No studies found 1,309 · 23.6%GRADE not reported 440 · 7.9%Very low 1,560 · 28.2%Low 1,292 · 23.3%Moderate 751 · 13.6%High 185 · 3.3%

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Immunosuppressive treatment vs placebo/no treatment/non‐immunosuppressive supportive treatment

Adverse events: malignancy · primary membranous nephropathy in adults with nephrotic syndrome

It is very uncertain whether immunosuppressive treatment changes adverse events: malignancy at final compared with placebo/no treatment/non‐immunosuppressive supportive treatment (very low certainty).

1 finding from 1 review

Chinese herbal medicine (CHM) + follicle aspiration + ovulation induction vs follicle aspiration + ovulation induction

Adverse event ‐ multiple pregnancy · subfertile women with PCOS

It is very uncertain whether chinese herbal medicine (CHM) plus follicle aspiration plus… changes multiple pregnancy (adverse events) compared with follicle aspiration plus ovulation induction (very low certainty).

1 finding from 1 review

Hydromorphone vs morphine

Dizziness · people with moderate to severe cancer pain

It is very uncertain whether hydromorphone changes specific adverse events – dizziness compared with morphine (very low certainty).

1 finding from 1 review

Hydromorphone vs fentanyl

Dizziness · people with moderate to severe cancer pain

The review found no eligible studies for this question.

1 finding from 1 review

Hydromorphone vs oxycodone

Dizziness · people with moderate to severe cancer pain

It is very uncertain whether hydromorphone changes specific adverse events – dizziness compared with oxycodone (very low certainty).

1 finding from 1 review

Intervention not reported

MST vs ECT ‐ serious adverse events · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Oral olesoxime vs placebo

Adverse events related to treatment · non‐ambulatory children and adolescents with SMA types II and III

Oral olesoxime probably leads to lower adverse events related to treatment compared with placebo (moderate certainty).

1 finding from 1 review