Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,918 questions · 5,537 findings · 1,803 reviews

No studies found 1,309 · 23.6%GRADE not reported 440 · 7.9%Very low 1,560 · 28.2%Low 1,292 · 23.3%Moderate 751 · 13.6%High 185 · 3.3%

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Saline vs carbon dioxide

Adverse events and complications · women undergoing outpatient hysteroscopy

Saline probably leads to lower adverse events and complications compared with carbon dioxide (moderate certainty).

1 finding from 1 review

Hydromorphone vs morphine

Nausea · people with moderate to severe cancer pain

It is very uncertain whether hydromorphone changes specific adverse events – nausea compared with morphine (very low certainty).

1 finding from 1 review

Hydromorphone vs fentanyl

Nausea · people with moderate to severe cancer pain

The review found no eligible studies for this question.

1 finding from 1 review

Hydromorphone vs oxycodone

Nausea · people with moderate to severe cancer pain

It is very uncertain whether hydromorphone changes specific adverse events – nausea compared with oxycodone (very low certainty).

1 finding from 1 review

Antihypertensive drug therapy vs placebo or no treatment

Withdrawals due to adverse events · adults (18 years of age or older) with hypertension‐induced left ventricular hypertrophy

It is very uncertain whether antihypertensive therapy changes withdrawal due to adverse events compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Efficacy and safety of a first dose of whole‐cell pertussis vaccine vs a first dose of acellular pertussis vaccine

All‐cause serious adverse events · the promotion of growth and prevention of infections in infants less than six months of age

Efficacy and safety of a first dose of whole‐cell pertussis vaccine showed no clear difference in all‐cause serious adverse events compared with a first dose of acellular pertussis vaccine (moderate certainty).

1 finding from 1 review