Findings

What do systematic reviews say?

132 questions · 133 findings · 46 reviews · Headline outcomes only

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No studies found 21 · 15.8%GRADE not reported 2 · 1.5%Very low 66 · 49.6%Low 24 · 18%Moderate 19 · 14.3%High 1 · 0.8%

Intervention not reported

Adverse effects of treatment · people with β‐thalassaemia and osteoporosis

The review found no eligible studies for this question.

1 finding from 1 review

Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Zinc vs placebo

Adverse effects of treatment · children and adults with β‐thalassaemia major and low bone mass

The review found no eligible studies for this question.

1 finding from 1 review

Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings – denosumab vs placebo

Adverse effects of treatment · adults with β‐thalassaemia and low bone mass

The review found no eligible studies for this question.

1 finding from 1 review

Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings – strontium ranelate vs placebo

Adverse effects of treatment · women with low bone mass and β‐thalassaemia

The review found no eligible studies for this question.

1 finding from 1 review

Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Bisphosphonates vs placebo or no treatment

Adverse effects of treatment · adults with β‐thalassaemia and osteoporosis

It is very uncertain whether summary of findings – bisphosphonates changes adverse effects of treatment compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
OR 15
2 studies · 143 participants
Very low

Balneotherapy vs melilotus officinalis

Adverse effects of treatment · people with chronic venous insufficiency

The review found no eligible studies for this question.

1 finding from 1 review

Balneotherapy for chronic venous insufficiency 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Balneotherapy vs dryland exercise

Adverse effects of treatment · people with chronic venous insufficiency

The review found no eligible studies for this question.

1 finding from 1 review

Balneotherapy for chronic venous insufficiency 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral plus nebulised antibiotics vs oral antibiotics plus nebulised placebo

Adverse effects of treatment · adults and children with cystic fibrosis and a positive microbiological isolate of MRSA from a respiratory tract specimen

Oral plus nebulised antibiotics showed no clear difference in adverse effects of treatment compared with oral antibiotics plus nebulised placebo (low certainty).

1 finding from 1 review

Interventions for the eradication of meticillin‐resistant Staphylococcus aureus (MRSA) in people with cystic fibrosis 2022 · Cochrane Headline outcomes only
OR 3 [0.11, 79.91]
1 study · 29 participants
Low

Active treatment vs observation

Adverse effects of treatment · adults or children with positive microbiological isolate of MRSA from a respiratory tract specimen

1 finding from 1 review

Interventions for the eradication of meticillin‐resistant Staphylococcus aureus (MRSA) in people with cystic fibrosis 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 45 participants
Low

Prophylactic LMWH vs placebo

Adverse effects of treatment · people with ST of the leg

The review found no eligible studies for this question.

1 finding from 1 review

Treatment for superficial thrombophlebitis of the leg 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Therapeutic LMWH vs placebo

Adverse effects of treatment · people with ST of the leg

The review found no eligible studies for this question.

1 finding from 1 review

Treatment for superficial thrombophlebitis of the leg 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NSAIDs vs placebo

Adverse effects of treatment · people with superficial thrombophlebitis of the leg

The review found no eligible studies for this question.

1 finding from 1 review

Treatment for superficial thrombophlebitis of the leg 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Fondaparinux vs placebo

Adverse effects of treatment · people with ST of the leg

Fondaparinux showed no clear difference in adverse effects of treatment compared with placebo (moderate certainty).

1 finding from 1 review

Treatment for superficial thrombophlebitis of the leg 2018 · Cochrane Headline outcomes only
RR 1.13 [0.78, 1.65]
1 study · 2987 participants
Moderate

Intervention not reported

Adverse effects of treatment · people with chronic hip, knee or hip and knee osteoarthritis

The review found no eligible studies for this question.

1 finding from 1 review

Exercise interventions and patient beliefs for people with hip, knee or hip and knee osteoarthritis: a mixed methods… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Adverse effects of treatment · adults over 18 years with tinnitus

The review found no eligible studies for this question.

1 finding from 1 review

Zinc supplementation for tinnitus 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings table ‐ Metformin + megestrol vs megestrol

Adverse effects during treatment · endometrial hyerplasia

1 finding from 1 review

Metformin for endometrial hyperplasia 2024 · Cochrane Headline outcomes only
no estimate extracted
1 study · 8 participants
Very low

Injectional interferon alpha‐2B vs Normal saline

Treatment‐related adverse effects · men with chronic (≥ 12 months) Peyronie's disease (single plaque)

The review found no eligible studies for this question.

1 finding from 1 review

Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Injectional nicardipine vs Normal saline

Treatment‐related adverse effects · men with chronic Peyronie's disease (plaques without calcification)

It is very uncertain whether injectional nicardipine changes treatment‐related adverse effects compared with saline (very low certainty).

1 finding from 1 review

Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
RR 2.82 [0.12, 66.62]
1 study · 62 participants
Very low

Injectional collagenase vs placebo

Treatment‐related adverse effects · men with Peyronie's disease (diagnosis of disease: at least 12 months, penile curvature: at least 30 degrees)

The review found no eligible studies for this question.

2 findings from 1 review

Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
RR 2.32 [1.98, 2.72]
1 study · 832 participants
Moderate

Potassium paraaminobenzoate vs placebo

Treatment‐related adverse effects · men with acute (maximum of 12 months) Peyronie's disease with no prior treatment and no evidence of calcified plaques (pain during…

It is very uncertain whether potassium paraaminobenzoate changes treatment‐related adverse effects compared with placebo (very low certainty).

1 finding from 1 review

Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
RR 1.27 [0.36, 4.48]
1 study · 103 participants
Very low