Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,949 questions · 1,994 findings · 636 reviews

No studies found 504 · 25.3%GRADE not reported 340 · 17.1%Very low 477 · 23.9%Low 390 · 19.6%Moderate 241 · 12.1%High 42 · 2.1%

Chlorhexidine dressing following alcohol cleansing vs polyurethane dressing following aqueous povidone‐iodine cleansing

Adverse effects: contact dermatitis · newborn infants with central venous catheters

Chlorhexidine dressing following alcohol cleansing probably leads to higher adverse effects: contact dermatitis compared with polyurethane dressing following aqueous povidone‐iodine cleansing (moderate certainty).

1 finding from 1 review

Benzodiazepines (topical clonazepam) vs placebo

Adverse effects: euphoric behaviour · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether benzodiazepines (topical clonazepam) changes adverse effects: euphoric behaviour compared with placebo (very low certainty).

1 finding from 1 review

Omega‐3 vs placebo

Adverse effects (any adverse effect) · sickle cell disease

It is very uncertain whether omega‐3 changes adverse effects (any adverse effect) compared with placebo (very low certainty).

1 finding from 1 review

Laxative vs placebo

Adverse effects on babies: diarrhoea · women in the postpartum period

It is very uncertain whether laxative changes adverse effects on babies: diarrhoea compared with placebo (very low certainty).

1 finding from 1 review

Combined oral contraceptive pill vs levonorgestrel intrauterine system

Adverse effects ‐ Any adverse events · heavy menstrual bleeding

It is very uncertain whether combined oral contraceptive pill changes adverse effects ‐ Any adverse events compared with levonorgestrel‐releasing intrauterine system (very low certainty).

1 finding from 1 review

Laparoscopic colposuspension with one suture vs laparoscopic colposuspension with two sutures

Adverse effects: voiding dysfunction · women with urinary incontinence

Laparoscopic colposuspension with one suture showed no clear difference in adverse effects: voiding dysfunction compared with laparoscopic colposuspension with two sutures (low certainty).

1 finding from 1 review