Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

32 questions · 32 findings · 20 reviews · Developmental, Psychosocial and Learning Problems

No studies found 13 · 40.6%GRADE not reported 2 · 6.3%Very low 5 · 15.6%Low 9 · 28.1%Moderate 3 · 9.4%High 0 · 0%

Attention deficit hyperactivity disorder (ADHD)‐related drugs vs placebo

Adverse effects · participants (any age) with a clinical diagnosis of ASD who have displayed one or more unwanted or challenging behaviours at baseline…

It is very uncertain whether attention deficit hyperactivity disorder (ADHD)‐related drugs changes adverse effects compared with placebo (very low certainty).

1 finding from 1 review

Neurohormones vs placebo

Adverse effects · participants (any age) with a clinical diagnosis of ASD who have displayed one or more unwanted or challenging behaviours at baseline…

It is very uncertain whether neurohormones changes adverse effects compared with placebo (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse effects · Children with cerebral palsy

The review found no eligible studies for this question.

1 finding from 1 review

Atypical antipsychotics vs placebo

Adverse effects (AEs) · participants (any age) with a clinical diagnosis of ASD who have displayed one or more unwanted or challenging behaviours at baseline…

Atypical antipsychotics may leads to higher adverse effects (AEs) compared with placebo (low certainty).

1 finding from 1 review

Intermittent use of iron supplements vs any daily iron supplementation

Side effects or other adverse events · adolescent and adult menstruating women

Intermittent iron supplementation may leads to lower any adverse side effects compared with daily iron supplementation (low certainty).

1 finding from 1 review

Intermittent iron supplementation (alone or with any other micronutrients) vs no supplementation or placebo

Side effects or other adverse events · adolescent and adult menstruating women

Intermittent iron supplementation (alone or with any other… showed no clear difference in any adverse side effects compared with no supplementation or placebo (moderate certainty).

1 finding from 1 review

Prophylactic probiotics vs placebo

Adverse effects Measured by: reporting · infants without colic

Prophylactic probiotics showed no clear difference in adverse effects Measured by: reporting compared with placebo (low certainty).

1 finding from 1 review