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Evidence found and GRADE certainty

1,949 questions · 1,994 findings · 636 reviews

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No studies found 504 · 25.3%GRADE not reported 340 · 17.1%Very low 477 · 23.9%Low 390 · 19.6%Moderate 241 · 12.1%High 42 · 2.1%

GTR rm + CAF vs SCTG + CAF

Occurrence of adverse effects or postoperative complications · Adult patients with single (localised) recession-type defects (Miller Class I/II, at least 3 mm)
1 finding from 1 review

ARIPIPRAZOLE (IM) vs OLANZAPINE

Adverse effects: one or more adverse effects during 24 hours · psychosis‐induced aggression or agitation (rapid tranquillisation)

It is very uncertain whether ARIPIPRAZOLE (IM) changes adverse effects: one or more adverse effects during 24 hours compared with OTHER ANTIPSYCHOTIC: b. OLANZAPINE (very low certainty).

1 finding from 1 review

Zuclopenthixol dihydrochloride (Cis Z isomer) vs Zuclopenthixol (Cis Z/Trans E isomer)

Adverse effects: Clinically important general adverse effect (no data) · schizophrenia

It is very uncertain whether zuclopenthixol dihydrochloride (Cis Z isomer) changes adverse effects: Clinically important general adverse effect compared with zuclopenthixol (Cis Z/Trans E isomer) (very low certainty).

1 finding from 1 review

CHLORPROMAZINE vs metiapine

Adverse effects. Specific: movement disorders ‐ parkinsonism · patients with schizophrenia

It is very uncertain whether chlorpromazine changes adverse effects. Specific: movement disorders ‐ parkinsonism compared with metiapine (very low certainty).

1 finding from 1 review

Impregnated catheters vs non‐impregnated catheters

Adverse effects (combined) Clinical assessment · Adult patients who required central venous catheters

Impregnated catheters showed no clear difference in adverse effects (combined) Identified by clinical assessment compared with non‐impregnated catheters (high certainty).

1 finding from 1 review

Ethinyl estradiol 35 μg + cyproterone acetate 2 mg vs ethinyloestradiol and norgestrel

Number of participants reporting non‐serious adverse effects · participants with hidradenitis suppurativa

Ethinyloestradiol and cyproterone acetate probably leads to lower number of participants reporting non‐serious adverse effects compared with ethinyloestradiol and norgestrel (moderate certainty).

1 finding from 1 review

HAART regimen + topical treatment vs HAART alone

Adverse effects of long‐term use of available topical agents · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers

The review found no eligible studies for this question.

1 finding from 1 review
  • Topical treatments for HIV‐related oral ulcers 2012 · Cochrane All outcomes
    No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6…
    0 studies
    No studies found

Topical corticosteroids vs Another topical agent or placebo

Adverse effects of long‐term use of available topical agents · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers

The review found no eligible studies for this question.

1 finding from 1 review
  • Topical treatments for HIV‐related oral ulcers 2012 · Cochrane All outcomes
    No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6…
    0 studies
    No studies found

Topical thalidomide vs Another topical agent or placebo

Adverse effects of long‐term use of available topical agents · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers

The review found no eligible studies for this question.

1 finding from 1 review
  • Topical treatments for HIV‐related oral ulcers 2012 · Cochrane All outcomes
    No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6…
    0 studies
    No studies found

Antiseptic mouthwash (e.g. chlorhexidine) vs Another topical agent or placebo

Adverse effects of long‐term use of available topical agents · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers

The review found no eligible studies for this question.

1 finding from 1 review
  • Topical treatments for HIV‐related oral ulcers 2012 · Cochrane All outcomes
    No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6…
    0 studies
    No studies found

Summary of findings table ‐ Metformin + levonorgestrel (intrauterine system) vs levonorgestrel intrauterine system

Adverse effects during treatment ‐ heaviness in lower abdomen · endometrial hyperplasia

It is very uncertain whether summary of findings table ‐ Metformin + levonorgestrel (intrauterine… changes adverse effects during treatment ‐ heaviness in lower abdomen compared with levonorgestrel intrauterine system (very low certainty).

1 finding from 1 review

IVIg vs different infusion regimens of IVIG

Incidence of any adverse effects after treatment initiation ( · people undergoing initial treatment for KD

Primary treatment with intravenous immunoglobulin (IVIG) showed no clear difference in incidence of any adverse effects after treatment initiation ( compared with different infusion regimens of IVIG (low certainty).

1 finding from 1 review