Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,949 questions · 1,994 findings · 636 reviews

No studies found 504 · 25.3%GRADE not reported 340 · 17.1%Very low 477 · 23.9%Low 390 · 19.6%Moderate 241 · 12.1%High 42 · 2.1%

Intervention not reported

Discontinuation of therapy due to adverse effects · patients in primary prevention of cardiovascular disease events

It is very uncertain whether the intervention changes discontinuation of therapy due to adverse effects (very low certainty).

1 finding from 1 review

Antioxidants vs control intervention

Adverse effects—cross‐over trials (unpaired data) · patients with chronic pancreatitis and pancreatic pain

Antioxidant probably leads to higher adverse effects—cross‐over trials (unpaired data) compared with control intervention (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Metformin + levonorgestrel (intrauterine system) vs levonorgestrel intrauterine system

Adverse effects during treatment ‐ pain in abdomen · endometrial hyperplasia

It is very uncertain whether summary of findings table ‐ Metformin + levonorgestrel (intrauterine… changes adverse effects during treatment ‐ pain in abdomen compared with levonorgestrel intrauterine system (very low certainty).

1 finding from 1 review

Summary of findings ‐ withdrawal of penicillin prophylaxis vs continuation

Nausea and vomiting · children with SCD who have been receiving prophylactic penicillin for at least two years

Summary of findings ‐ withdrawal of penicillin prophylaxis showed no clear difference in adverse effects: incidences of nausea and vomiting compared with continuation (low certainty).

1 finding from 1 review

Chemotherapy (any regimen; added to, or compared with, locoregional treatment) vs Locoregional treatment and/or an alternative chemotherapy regimen

Toxicity / adverse effects (harms) of chemotherapy · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
1 finding from 1 review

RISPERIDONE vs COMBINATION: a. RISPERIDONE + OXCARBAZEPINE

Adverse effects ‐ movement disorders · psychosis‐induced aggression or agitation (rapid tranquillisation)

It is very uncertain whether RISPERIDONE changes adverse effects: movement disorders, over 24 hours compared with COMBINATION: a. RISPERIDONE + OXCARBAZEPINE (very low certainty).

1 finding from 1 review

RISPERIDONE vs COMBINATION: b. RISPERIDONE + VALPROIC ACID

Adverse effects ‐ movement disorders · psychosis‐induced aggression or agitation (rapid tranquillisation)

It is very uncertain whether RISPERIDONE changes adverse effects: movement disorders, over 24 hours compared with COMBINATION: b. RISPERIDONE + VALPROIC ACID (very low certainty).

1 finding from 1 review

Droperidol vs placebo

Adverse effects ‐ respiratory ‐ airway obstruction · acute psychosis

Droperidol showed no clear difference in adverse effects ‐ respiratory ‐ airway obstruction compared with placebo (low certainty).

1 finding from 1 review

Any antiglucocorticoid vs placebo

Adverse effects: 1. General ‐ overall number of events · people with psychosis

Any antiglucocorticoid probably leads to higher adverse effects: 1. General ‐ overall number of events compared with placebo (moderate certainty).

2 findings from 1 review