What do systematic reviews say?

High‐dose vs low‐dose coenzyme Q10 and vitamin E

• Treatment for speech disorder in Friedreich ataxia and other hereditary ataxia syndromes 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 50 participants
  GRADE not reported

Buspirone vs placebo

• Treatment for speech disorder in Friedreich ataxia and other hereditary ataxia syndromes 2014 · Cochrane Headline outcomes only
  no estimate extracted
  19 participants
  GRADE not reported

α‐tocopheryl quinone vs placebo

• Treatment for speech disorder in Friedreich ataxia and other hereditary ataxia syndromes 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 31 participants
  GRADE not reported

Erythropoietin vs placebo

• Treatment for speech disorder in Friedreich ataxia and other hereditary ataxia syndromes 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 16 participants
  GRADE not reported

FLUPHENAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS

FLUPHENAZINE leads to lower adverse effects‐other‐sedation compared with LOW‐POTENCY ANTIPSYCHOTIC DRUGS (high certainty).

• Fluphenazine versus low‐potency first‐generation antipsychotic drugs for schizophrenia 2014 · Cochrane Headline outcomes only
  RR 0.31 [0.13, 0.77]
  1 study · 65 participants
  High

Proparacaine hydrochloride 0.5% eye drops vs placebo

• Non‐antiepileptic drugs for trigeminal neuralgia 2013 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 47 participants
  GRADE not reported

Tizanidine vs carbamazepine

• Non‐antiepileptic drugs for trigeminal neuralgia 2013 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 11 participants
  GRADE not reported

Intervention not reported

• Interventions for drooling in children with cerebral palsy 2012 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low

Intervention not reported

• Green tea for weight loss and weight maintenance in overweight or obese adults 2012 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Ergonomic keyboard vs placebo

The review found no eligible studies for this question.

• Ergonomic positioning or equipment for treating carpal tunnel syndrome 2012 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Oral steroids vs control

• Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children 2011 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 143 participants
  GRADE not reported

Orthodontic treatment with appliances inducing stable, permanent orthodontic tooth movement (splints worn 8 to 12 weeks and surgical interventions excluded) vs Control: no treatment, placebo, or reassurance

The review found no eligible studies for this question.

• Orthodontics for treating temporomandibular joint (TMJ) disorders 2010 · Cochrane All outcomes

  At least 6 months after the intervention
  no estimate extracted
  0 studies
  No studies found

CLOZAPINE vs Typical antipsychotics

CLOZAPINE probably leads to higher adverse effects 5. Weight gain compared with TYPICAL ANTIPSYCHOTICS (moderate certainty).

• Clozapine versus typical neuroleptic medication for schizophrenia 2009 · Cochrane Headline outcomes only
  RR 1.33 [1.11, 1.59]
  3 studies · 484 participants
  Moderate
• Clozapine versus typical neuroleptic medication for schizophrenia 2009 · Cochrane Headline outcomes only
  RR 1.28 [1.07, 1.53]
  5 studies · 590 participants
  Moderate

Intravenous ceftazidime with tobramycin vs ciprofloxacin

Intravenous ceftazidime with tobramycin probably leads to lower adverse effects of antibiotics: compared with oral ciprofloxacin (moderate certainty).

• Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
  RR 0.97
  1 study · 285 participants
  Moderate

Intervention not reported

The review found no eligible studies for this question.

• Lay health workers in primary and community health care for maternal and child health: identification and treatment of… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Lay health workers in primary and community health care for maternal and child health: identification and treatment of… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antipsychotics vs placebo

The review found no eligible studies for this question.

• Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antidepressants vs antidepressants

The review found no eligible studies for this question.

• Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antidepressants vs antipsychotics

The review found no eligible studies for this question.

• Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antidepressant plus antipsychotic vs placebo

The review found no eligible studies for this question.

• Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found