Question · asked by 1 review
Tricyclic antidepressants vs SSRI: Withdrawals due to adverse events
- Population
- adults with panic disorder
- Intervention
- Tricyclic antidepressants
- Comparison
- SSRI
- Outcome
- Withdrawals due to adverse events
TCAs showed no clear difference in number of dropouts due to adverse effects compared with SSRI (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
TCAs vs SSRI number of dropouts due to adverse effects · adults with panic disorder TCAs showed no clear difference in number of dropouts due to adverse effects compared with SSRI (low certainty). Antidepressants and benzodiazepines for panic disorder in adults (2016) · Cochrane Headline outcomes only | RR 1.43 [0.82, 2.48] | 5 studies · 476 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
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How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.