Studies
Primary studies
26,293 studies included by 1,022 non-Cochrane dental reviews extracted from full text, one record per study, so a study included by several reviews is counted once. Most are randomized trials; etiology and diagnostic reviews also include observational and accuracy studies. Cochrane reviews and reviews with only their headline outcomes do not list their included studies here yet.
ReviewStudies included by Clinical efficacy of different biomaterials for the regenerative treatment of periodontal intrabony defects: a systematic review and…. Show all studies
| Study | Year | Reviews | Review outcomes linked | Trial data |
|---|---|---|---|---|
| Human intrabony defect regeneration with micrografts containing dental pulp stem cells: A randomized controlled clinical trial. Ferrarotti 2018 · Ferrarotti Francesco, Romano Federica, et al. · Journal of clinical periodontology PMID:29779220 | 2018 | 5 | none stated | not extracted yet |
| Platelet-Rich Fibrin Combined With 1.2% Atorvastatin for Treatment of Intrabony Defects in Chronic Periodontitis: A Randomized Controlled Clinical… Martande 2016 · Martande Santosh S, Kumari Minal, et al. · Journal of periodontology PMID:27294433 | 2016 | 4 | 4 | not extracted yet |
| Adjunctive effect of collagen membrane coverage to L-PRF in the treatment of periodontal intrabony defects: a randomized controlled clinical trial… Mubarak 2023 · Mubarak Ramy, Adel-Khattab Doaa, et al. · BMC oral health PMID:37667213 | 2023 | 3 | none stated | not extracted yet |
| Treatment of periodontal intrabony defects using bovine porous bone mineral and guided tissue regeneration with/without platelet-rich fibrin: A… Liu 2021 · Liu Kaining, Huang Zhen, et al. · Journal of periodontology PMID:33569807 | 2021 | 3 | none stated | not extracted yet |
| Clinical, radiographic, and patient‐centered outcomes after use of enamel matrix proteins for the treatment of intrabony defects in patients with… Mazzonetto 2020 · Fileto Mazzonetto Ana Lívia, Casarin Renato Corrêa Viana, et al. · Journal of Periodontology DOI:10.1002/jper.20-0493 | 2020 | 3 | none stated | not extracted yet |
| Synergistic Approach Using Platelet-Rich Fibrin and 1% Alendronate for Intrabony Defect Treatment in Chronic Periodontitis: A Randomized Clinical… Kanoriya 2016a · Kanoriya Dharmendra, Pradeep A R, et al. · Journal of periodontology PMID:27562221 | 2016 | 3 | 2 | not extracted yet |
| Comparision of crosslinked hyaluronic acid vs. enamel matrix derivative for periodontal regeneration: an 18-month follow-up randomized clinical trial. Rodríguez et al., 2025 · Rodríguez-A Manuel, Montiel-Company Jose María, et al. · Clinical oral investigations PMID:40106008 | 2025 | 2 | none stated | not extracted yet |
| Platelet Rich Fibrin Matrix (PRFM) and Peripheral Blood Mesenchymal Stem Cells (PBMSCs) in the management of intraosseous defects - A randomized… Sreeparvathy 2024 · SREEPARVATHY R, BELLUDI Sphoorthi Anup, et al. · Journal of Applied Oral Science DOI:10.1590/1678-7757-2023-0442 | 2024 | 2 | none stated | not extracted yet |
| The effect of titanium-platelet rich fibrin on periodontal intrabony defects: A randomized controlled split-mouth clinical study. Ozkal Eminoglu 2024 · Ozkal Eminoglu Didem, Arabaci Taner, et al. · PloS one PMID:38843242 | 2024 | 2 | 1 | not extracted yet |
| Platelet Rich Fibrin Matrix (PRFM) and Peripheral Blood Mesenchymal Stem Cells (PBMSCs) in the management of intraosseous defects - A randomized… Sreeparvathy 2024 · Sreeparvathy R, Belludi Sphoorthi Anup, et al. · Journal of applied oral science : revista FOB PMID:39109750 | 2024 | 2 | none stated | not extracted yet |
| Adjunctive effect of collagen membrane coverage to L-PRF in the treatment of periodontal intrabony defects: a randomized controlled clinical trial… Mubarak 2023 · Mubarak Ramy, Adel-Khattab Doaa, et al. · BMC Oral Health DOI:10.1186/s12903-023-03332-0 | 2023 | 2 | none stated | not extracted yet |
| The use of integrin binding domain loaded hydrogel (RGD) with minimally invasive surgical technique in treatment of periodontal intrabony defect: a… Abd El-Azeem 2023 · Abd El-Azeem Shaimaa Hamdy, Khalil Ahmed Abdallah, et al. · Journal of applied oral science : revista FOB PMID:38126565 | 2023 | 2 | none stated | not extracted yet |
| Comparative evaluation of demineralized freeze-dried bone allograft with and without concentrated growth factor membrane in the treatment of… Samarth 2023 · Samarth Gopal, Kolte Abhay, et al. · Clinical Oral Investigations DOI:10.1007/s00784-022-04791-5 | 2022 | 2 | 3 | not extracted yet |
| Treatment of periodontal intrabony defects using bovine porous bone mineral and guided tissue regeneration with/without platelet‐rich fibrin: A… Liu 2021 · Liu Kaining, Huang Zhen, et al. · Journal of Periodontology DOI:10.1002/jper.20-0860 | 2021 | 2 | none stated | not extracted yet |
| Clinical, radiographic, and patient-centered outcomes after use of enamel matrix proteins for the treatment of intrabony defects in patients with… Mazzonetto 2021 · Fileto Mazzonetto Ana Lívia, Casarin Renato Corrêa Viana, et al. · Journal of periodontology PMID:33107596 | 2021 | 2 | none stated | not extracted yet |
| Human intrabony defect regeneration with micrografts containing dental pulp stem cells: A randomized controlled clinical trial Ferrarotti 2018 · Ferrarotti Francesco, Romano Federica, et al. · Journal of Clinical Periodontology DOI:10.1111/jcpe.12931 | 2018 | 2 | none stated | not extracted yet |
| Treatment of intrabony defects with modified perforated membranes in aggressive periodontitis: a 12-month randomized controlled trial. Gorski 2018 · Górski Bartłomiej, Jalowski Stanisław, et al. · Clinical oral investigations PMID:29411112 | 2018 | 2 | none stated | not extracted yet |
| Adjunctive Effect of Autologous Platelet-Rich Fibrin in the Treatment of Intrabony Defects in Localized Aggressive Periodontitis Patients: A… Thorat 2017 · Thorat ManojKumar, Baghele Om, et al. · The International Journal of Periodontics & Restorative Dentistry DOI:10.11607/prd.2972 | 2017 | 2 | none stated | not extracted yet |
| Autologous Platelet‐Rich Fibrin in the Treatment of 3‐Wall Intrabony Defects in Aggressive Periodontitis: A Randomized Controlled Clinical Trial Bajaj 2017 · Bajaj Pavan, Agarwal Esha, et al. · Journal of Periodontology DOI:10.1902/jop.2017.120661 | 2017 | 2 | none stated | not extracted yet |
| Treatment of periodontal intrabony defects using autologous platelet-rich fibrin and titanium platelet-rich fibrin: a randomized, clinical,… Chatterjee 2016 · Chatterjee Anirban, Pradeep Avani R, et al. · Journal of investigative and clinical dentistry PMID:27477110 | 2017 | 2 | none stated | not extracted yet |
| Autologous Platelet-Rich Fibrin in the Treatment of 3-Wall Intrabony Defects in Aggressive Periodontitis: A Randomized Controlled Clinical Trial. Bajaj 2017 · Bajaj Pavan, Agarwal Esha, et al. · Journal of periodontology PMID:28820320 | 2017 | 2 | none stated | not extracted yet |
| Adjunctive Effect of Autologous Platelet-Rich Fibrin in the Treatment of Intrabony Defects in Localized Aggressive Periodontitis Patients: A… Thorat 2017 · Thorat ManojKumar, Baghele Om N, et al. · The International journal of periodontics & restorative dentistry PMID:29023611 | 2017 | 2 | none stated | not extracted yet |
| Treatment of periodontal intrabony defects using autologous platelet‐rich fibrin and titanium platelet‐rich fibrin: a randomized, clinical,… Chatterjee 2016 · Chatterjee Anirban, Pradeep Avani R., et al. · Journal of Investigative and Clinical Dentistry DOI:10.1111/jicd.12231 | 2016 | 2 | none stated | not extracted yet |
| Platelet‐Rich Fibrin Combined With 1.2% Atorvastatin for Treatment of Intrabony Defects in Chronic Periodontitis: A Randomized Controlled Clinical… Martande 2012 · Martande Santosh S., Kumari Minal, et al. · Journal of Periodontology DOI:10.1902/jop.2016.150306 | 2016 | 2 | none stated | not extracted yet |
| Synergistic Approach Using Platelet‐Rich Fibrin and 1% Alendronate for Intrabony Defect Treatment in Chronic Periodontitis: A Randomized Clinical… Pradeep 2016 · Kanoriya Dharmendra, Pradeep A.R., et al. · Journal of Periodontology DOI:10.1902/jop.2016.150698 | 2016 | 2 | none stated | not extracted yet |
| Human intrabony defect regeneration with rh <scp>FGF</scp> ‐2 and hyaluronic acid – a randomized controlled clinical trial de Santana 2015 · de Santana Ronaldo Barcellos, de Santana Carolina Miller Mattos · Journal of Clinical Periodontology DOI:10.1111/jcpe.12406 | 2015 | 2 | none stated | not extracted yet |
| Comparative Evaluation of Autologous Platelet‐Rich Fibrin and Platelet‐Rich Plasma in the Treatment of 3‐Wall Intrabony Defects in Chronic… Pradeep 2012 · Pradeep A.R., Rao Nishanth S., et al. · Journal of Periodontology DOI:10.1902/jop.2012.110705 | 2012 | 2 | none stated | not extracted yet |
| Comparative evaluation of autologous platelet-rich fibrin and platelet-rich plasma in the treatment of 3-wall intrabony defects in chronic… Pradeep 2012 · Pradeep A R, Rao Nishanth S, et al. · Journal of periodontology PMID:22348695 | 2012 | 2 | none stated | not extracted yet |
| Autogenous Periosteal Barrier Membranes and Bone Grafts in the Treatment of Periodontal Intrabony Defects of Single‐Rooted Teeth: A 12‐Month Reentry… Paolantonio 2010 · Paolantonio Michele, Femminella Beatrice, et al. · Journal of Periodontology DOI:10.1902/jop.2010.100094 | 2010 | 2 | none stated | not extracted yet |
| Comparision of crosslinked hyaluronic acid vs. enamel matrix derivative for periodontal regeneration: an 18-month follow-up randomized clinical trial Rodríguez 2025 · Rodríguez-A Manuel, Montiel-Company Jose María, et al. · Clinical Oral Investigations DOI:10.1007/s00784-025-06278-5 | 2025 | 1 | none stated | not extracted yet |
| Effect of 0.8% Hyaluronic Acid-Based Gel on Clinical and Biomolecular parameters in the surgical periodontal treatment of Stage III periodontitis… Şener 2025 · Şener Aslı, Dede Figen Öngöz, et al. · Clinical Oral Investigations DOI:10.1007/s00784-025-06449-4 | 2025 | 1 | none stated | not extracted yet |
| Effect of 0.8% Hyaluronic Acid-Based Gel on Clinical and Biomolecular parameters in the surgical periodontal treatment of Stage III periodontitis… Sener 2025 · Şener Aslı, Dede Figen Öngöz, et al. · Clinical oral investigations PMID:40643719 | 2025 | 1 | none stated | not extracted yet |
| Periodontal regenerative therapy using recombinant human fibroblast growth factor (rhFGF)-2 in combination with carbonate apatite granules or… Imamura 2024 · Imamura Kentaro, Yoshida Wataru, et al. · Clinical Oral Investigations DOI:10.1007/s00784-024-05979-7 | 2024 | 1 | none stated | not extracted yet |
| Recombinant human fibroblast growth factor and autogenous bone for periodontal regeneration: Alone or in combination? A randomized clinical trial Kojima 2024 · Kojima Kosuke, Kamata Yohei, et al. · Journal of Periodontal Research DOI:10.1111/jre.13310 | 2024 | 1 | none stated | not extracted yet |
| The effect of titanium-platelet rich fibrin on periodontal intrabony defects: A randomized controlled split-mouth clinical study Ozkal Eminoglu 2024 · Ozkal Eminoglu Didem, Arabaci Taner, et al. · PLOS ONE DOI:10.1371/journal.pone.0304970 | 2024 | 1 | none stated | not extracted yet |
| Clinical and radiographic evaluation of the use of PRF, CGF, and autogenous bone in the treatment of periodontal intrabony defects: Treatment of… Alshujaa 2024 · Alshujaa Basem, Talmac Ahmet Cemil, et al. · Journal of periodontology PMID:37986648 | 2024 | 1 | none stated | not extracted yet |
| Recombinant human fibroblast growth factor and autogenous bone for periodontal regeneration: Alone or in combination? A randomized clinical trial. Kojima 2024 · Kojima Kosuke, Kamata Yohei, et al. · Journal of periodontal research PMID:38853125 | 2024 | 1 | none stated | not extracted yet |
| Periodontal regenerative therapy using recombinant human fibroblast growth factor (rhFGF)-2 in combination with carbonate apatite granules or… Imamura 2024 · Imamura Kentaro, Yoshida Wataru, et al. · Clinical oral investigations PMID:39373727 | 2024 | 1 | none stated | not extracted yet |
| Clinical and radiographic evaluation of the use of PRF, CGF, and autogenous bone in the treatment of periodontal intrabony defects: Treatment of… Alshujaa 2024 · Alshujaa Basem, Talmac Ahmet Cemil, et al. · Journal of Periodontology DOI:10.1002/jper.23-0481 | 2023 | 1 | none stated | not extracted yet |
| The use of integrin binding domain loaded hydrogel (RGD) with minimally invasive surgical technique in treatment of periodontal intrabony defect: a… Abd El-Azeem 2023 · ABD EL-AZEEM Shaimaa Hamdy, KHALIL Ahmed Abdallah, et al. · Journal of Applied Oral Science DOI:10.1590/1678-7757-2023-0263 | 2023 | 1 | none stated | not extracted yet |
| Comparative evaluation of demineralized freeze-dried bone allograft with and without concentrated growth factor membrane in the treatment of… Samarth 2022 · Samarth Gopal, Kolte Abhay, et al. · Clinical oral investigations PMID:36441270 | 2023 | 1 | none stated | not extracted yet |
| Clinical and radiographic evaluation of low-speed platelet-rich fibrin (PRF) for the treatment of intra-osseous defects of stage-III periodontitis… Abdulrahman 2022 · Abdulrahman Yasser Ali, Hosny Manal Mohamed, et al. · Clinical Oral Investigations DOI:10.1007/s00784-022-04627-2 | 2022 | 1 | none stated | not extracted yet |
| Long-term stability of adjunctive use of enamel matrix protein derivative on porcine-derived xenograft for the treatment of one-wall intrabony… Lee & Jeong 2021 · Lee Jae-Hong, Jeong Seong-Nyum · Journal of periodontology PMID:34050681 | 2022 | 1 | none stated | not extracted yet |
| Clinical and radiographic evaluation of low-speed platelet-rich fibrin (PRF) for the treatment of intra-osseous defects of stage-III periodontitis… Abdulrahman 2022 · Abdulrahman Yasser Ali, Hosny Manal Mohamed, et al. · Clinical oral investigations PMID:35876893 | 2022 | 1 | none stated | not extracted yet |
| Periodontal Regenerative Therapy Using rhFGF-2 and Deproteinized Bovine Bone Mineral versus rhFGF-2 Alone: 4-Year Extended Follow-Up of a Randomized… Seshima 2022 · Seshima Fumi, Bizenjima Takahiro, et al. · Biomolecules PMID:36421696 | 2022 | 1 | none stated | not extracted yet |
| Long‐term stability of adjunctive use of enamel matrix protein derivative on porcine‐derived xenograft for the treatment of one‐wall intrabony… Lee 2021 · Lee Jae‐Hong, Jeong Seong‐Nyum · Journal of Periodontology DOI:10.1002/jper.21-0254 | 2021 | 1 | none stated | not extracted yet |
| Clinical and radiographic effects of ascorbic acid-augmented platelet-rich fibrin versus platelet-rich fibrin alone in intra-osseous defects of… Elbehwashy 2021 · Elbehwashy Mohamed Talaat, Hosny Manal Mohamed, et al. · Clinical Oral Investigations DOI:10.1007/s00784-021-03929-1 | 2021 | 1 | none stated | not extracted yet |
| Clinical and radiographic effects of ascorbic acid-augmented platelet-rich fibrin versus platelet-rich fibrin alone in intra-osseous defects of… Elbehwashy 2021 · Elbehwashy Mohamed Talaat, Hosny Manal Mohamed, et al. · Clinical oral investigations PMID:33842996 | 2021 | 1 | none stated | not extracted yet |
| Clinical and radiographic evaluation of amnion chorion membrane and demineralized bone matrix putty allograft for management of periodontal… Temraz 2019 · Temraz Amr, Ghallab Noha A., et al. · Cell and Tissue Banking DOI:10.1007/s10561-018-09743-6 | 2019 | 1 | none stated | not extracted yet |
| Clinical and radiographic evaluation of amnion chorion membrane and demineralized bone matrix putty allograft for management of periodontal… Temraz 2019 · Temraz Amr, Ghallab Noha A, et al. · Cell and tissue banking PMID:30631986 | 2019 | 1 | none stated | not extracted yet |