evidencegaps
Primary study · included by 3 reviews

Synergistic Approach Using Platelet-Rich Fibrin and 1% Alendronate for Intrabony Defect Treatment in Chronic Periodontitis: A Randomized Clinical Trial.

Kanoriya 2016a · Kanoriya Dharmendra, Pradeep A R, Singhal Sandeep, et al. · Journal of periodontology · 2016

Included by

A network meta-analysis of randomized controlled trials evaluating the evidence of pharmacological agents and growth factors in the regeneration of bony defects in chronic periodontitis.
Non-Cochrane · intervention · 2026 · cited as Kanoriya 2016 (intrabony) · Table 1; Included studies
Outcome this study informsPooled effectEvidenceCertainty
Bone fill (BF)
Alendronate (ALN) plus platelet-rich fibrin (PRF) vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined)
SMD 2.45NRGRADE not reported
Clinical attachment level (CAL) gain
Alendronate (ALN) plus platelet-rich fibrin (PRF) vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined)
SMD 1.89NRGRADE not reported
Bone fill (BF)
Alendronate (ALN) plus platelet-rich fibrin (PRF) vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined)
SMD 2.32NRGRADE not reported
Bone fill (BF)
Alendronate (ALN) plus platelet-rich fibrin (PRF) vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined)
SMD 2.45 [2.34, 2.56]3 studiesGRADE not reported
Clinical attachment level (CAL) gain
Alendronate (ALN) plus platelet-rich fibrin (PRF) vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined)
SMD 1.89 [1.57, 2.21]3 studiesGRADE not reported
Clinical attachment level (CAL) gain
Alendronate (ALN) plus platelet-rich fibrin (PRF) vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined)
SMD 0.99NRGRADE not reported
Clinical efficacy of different biomaterials for the regenerative treatment of periodontal intrabony defects: a systematic review and Bayesian network meta-analysis.
Non-Cochrane · intervention · 2026 · cited as Pradeep 2016 · Table 1

The review does not say which of its outcomes this study informs.

Efficacy of Leukocyte and Platelet-Rich Fibrin (L-PRF) as an adjunct to Open Flap Debridement (OFD) in periodontal intrabony defects: a systematic review and meta-analysis.
Non-Cochrane · intervention · 2026 · cited as Kanoriya 2016 · Table 1; References 15-37

The review does not say which of its outcomes this study informs.

3 including reviews in total.