evidencegaps
Primary study · included by 4 reviews

Platelet-Rich Fibrin Combined With 1.2% Atorvastatin for Treatment of Intrabony Defects in Chronic Periodontitis: A Randomized Controlled Clinical Trial.

Martande 2016 · Martande Santosh S, Kumari Minal, Pradeep A R, et al. · Journal of periodontology · 2016

Included by

A network meta-analysis of randomized controlled trials evaluating the evidence of pharmacological agents and growth factors in the regeneration of bony defects in chronic periodontitis.
Non-Cochrane · intervention · 2026 · cited as Martande 2016 · Table 1; Included studies
Outcome this study informsPooled effectEvidenceCertainty
Clinical attachment level (CAL) gain
Atorvastatin (ATV) plus PRF vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined)
SMD 0.99NRGRADE not reported
Clinical attachment level (CAL) gain
Atorvastatin (ATV) plus PRF vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined)
SMD 1.20 [0.72, 1.69]1 studyGRADE not reported
Bone fill (BF)
Atorvastatin (ATV) plus PRF vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined)
SMD 2.29NRGRADE not reported
Bone fill (BF)
Atorvastatin (ATV) plus PRF vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined)
SMD 2.24NRGRADE not reported
Clinical attachment level (CAL) gain
Atorvastatin (ATV) plus PRF vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined)
SMD 1.20NRGRADE not reported
Bone fill (BF)
Atorvastatin (ATV) plus PRF vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined)
SMD 2.24 [2.11, 2.38]1 studyGRADE not reported
Adjunctive Use of Locally Delivered Statins in Periodontal Therapy and Pre-Implant Bone Regeneration: A Systematic Review and Meta-Analysis.
Non-Cochrane · intervention · 2026 · cited as Martande 2016 · Figures 2-4; Tables 4-5 and reference list
Outcome this study informsPooled effectEvidenceCertainty
Clinical attachment level (CAL), change from baseline (mm)
Open flap debridement with PRF (and HA in furcation) plus locally delivered statin gel (atorvastatin or rosuvastatin) vs Same surgical procedure without statin · 9 months
MD 0.69 [0.42, 0.96]3 studies · 190 participantsGRADE not reported
Probing pocket depth (PPD), change from baseline (mm)
Open flap debridement with PRF (and HA in furcation) plus locally delivered statin gel (atorvastatin or rosuvastatin) vs Same surgical procedure without statin · 9 months
MD 0.80 [0.56, 1.05]3 studies · 190 participantsGRADE not reported
Clinical efficacy of different biomaterials for the regenerative treatment of periodontal intrabony defects: a systematic review and Bayesian network meta-analysis.
Non-Cochrane · intervention · 2026 · cited as Martande 2012 · Table 1

The review does not say which of its outcomes this study informs.

Efficacy of Leukocyte and Platelet-Rich Fibrin (L-PRF) as an adjunct to Open Flap Debridement (OFD) in periodontal intrabony defects: a systematic review and meta-analysis.
Non-Cochrane · intervention · 2026 · cited as Martande 2016 · Table 1; References 15-37

The review does not say which of its outcomes this study informs.

4 including reviews in total.