Studies
Primary studies
26,293 studies included by 1,022 non-Cochrane dental reviews extracted from full text, one record per study, so a study included by several reviews is counted once. Most are randomized trials; etiology and diagnostic reviews also include observational and accuracy studies. Cochrane reviews and reviews with only their headline outcomes do not list their included studies here yet.
ReviewStudies included by Do Adjunctive Therapies with Natural Products Improve Periodontal Clinical Parameters After Non-Surgical Treatment? A Systematic Review…. Show all studies
| Study | Year | Reviews | Review outcomes linked | Trial data |
|---|---|---|---|---|
| Effect of subgingival application of topical ozonated olive oil in the treatment of chronic periodontitis: a randomized, controlled, double blind,… Patel 2012 · Patel P V, Patel A, et al. · Minerva stomatologica PMID:22976566 | 2012 | 4 | none stated | not extracted yet |
| Relaxation of smooth muscle following contraction elicited by sympathetic nerve stimulation in vivo. Wu 2023 · Eccles R, MacLean A G · British journal of pharmacology PMID:202357 | 1977 | 4 | 1 | not extracted yet |
| Clinical and microbiological outcomes of subgingival instrumentation supplemented with high-dose omega-3 polyunsaturated fatty acids in periodontal… Stańdo-Retecka et al. 2023 · Stańdo-Retecka Mirella, Piatek Paweł, et al. · BMC oral health PMID:37179297 | 2023 | 3 | none stated | not extracted yet |
| Efficacy of Cucurmin and Aloevera Extracts Gel as Local Drugs Delivery Agents. Borgohain 2023 · Borgohain Raktapratim, Fatima Nikhat, et al. · Journal of pharmacy & bioallied sciences PMID:37693983 | 2023 | 3 | 1 | not extracted yet |
| Effects of omega-3 supplementation as an adjunct to non-surgical periodontal therapy on periodontal parameters in periodontitis patients: a… Maybodi et al. 2022 · Maybodi Fahimeh Rashidi, Fakhari Mahsa, et al. · BMC oral health PMID:36414947 | 2022 | 3 | none stated | not extracted yet |
| Determination of efficacy of curcumin and Tulsi extracts as local drugs in periodontal pocket reduction: A clinical and microbiological study. Rahalkar 2021 · Rahalkar Apurva, Kumathalli Kanteshwari, et al. · Journal of Indian Society of Periodontology PMID:34158685 | 2021 | 3 | 1 | not extracted yet |
| Evaluation of superoxide dismutase levels in local drug delivery system containing 0.2% curcumin strip as an adjunct to scaling and root planing in… Elavarasu 2016 · Elavarasu Sugumari, Suthanthiran Thangakumaran, et al. · Journal of pharmacy & bioallied sciences PMID:27829747 | 2016 | 3 | 1 | not extracted yet |
| Adjunctive treatment of chronic periodontitis with daily dietary supplementation with omega-3 Fatty acids and low-dose aspirin. El-Sharkawy et al., 2010 · El-Sharkawy Hesham, Aboelsaad Nayer, et al. · Journal of periodontology PMID:20572767 | 2010 | 3 | none stated | not extracted yet |
| The nasal arteries. Wu 2021 · Osborn A G · AJR. American journal of roentgenology PMID:202158 | 1978 | 3 | none stated | not extracted yet |
| Costs and benefits of behavioural psychotherapy: a pilot study of neurotics treated by nurse-therapists. Musinguzi 2019 · Ginsberg G, Marks I · Psychological medicine PMID:201959 | 1977 | 3 | 1 | not extracted yet |
| Diuretics and the renal adenylate cyclase system. Lindsay et al. 2023 · Dawborn J K, Macneil S, et al. · British journal of pharmacology PMID:202362 | 1977 | 3 | none stated | not extracted yet |
| Evaluating the Efficacy of Resveratrol-Containing Mouthwash as an Adjunct Treatment for Periodontitis: A Randomized Clinical Trial. Mohammed et al., 2025 · Mohammed Sura A, Akram Hadeel Mazin · European journal of dentistry PMID:39251207 | 2025 | 2 | 4 | not extracted yet |
| Comparative Assessment of Subgingivally Delivered 2% Curcumin Gel as an Adjunct to Scaling and Root Planing in Smokers with Chronic Periodontitis: A… Gupta et al., 2025 · Gupta Shruti, Jyothi S G, et al. · Journal of pharmacy & bioallied sciences PMID:40655860 | 2025 | 2 | 2 | not extracted yet |
| Evaluation of nanofiber scaffolds laden Ashvakatri in the management of chronic periodontitis-a randomized, controlled split pocket study. Dubey et al., 2025 · Dubey Pragati, Mittal Neelam, et al. · Journal of oral biology and craniofacial research PMID:40895264 | 2025 | 2 | none stated | not extracted yet |
| Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical… Nikniaz et al., 2023 · Nikniaz Shabnam, Vaziri Farzane, et al. · BMC oral health PMID:36973728 | 2023 | 2 | 4 | not extracted yet |
| To Evaluate the Clinical Efficacy of 940 nm Diode Laser and Propolis Gel (A Natural Product) in Adjunct to Scaling and Root Planing in Treatment of… Aggarwal et al., 2023 · Aggarwal Rajni, Bawa Supneet S, et al. · Journal of pharmacy & bioallied sciences PMID:37694074 | 2023 | 2 | none stated | not extracted yet |
| Efficacy of curcumin gel as an adjunct to scaling and root planing on salivary procalcitonin level in the treatment of patients with chronic… Abdel-Fatah et al., 2023 · Abdel-Fatah Reham, Mowafey Bassant, et al. · BMC oral health PMID:37981665 | 2023 | 2 | 1 | not extracted yet |
| Efficacy of Sub-Gingivally Delivered Propolis Nanoparticle in Non-Surgical Management of Periodontal Pocket: A Randomized Clinical Trial. Sahu et al., 2023 · Sahu Sushree Ambika, Panda Saurav, et al. · Biomolecules PMID:38002260 | 2023 | 2 | none stated | not extracted yet |
| A clinical and microbiological study to assess the efficacy of Acmella oleracea and Acacia catechu herbs as local drug delivery in treatment of… Verma 2022 · Verma Kanika, Dhruvakumar Deepa, et al. · Journal of Indian Society of Periodontology PMID:35602538 | 2022 | 2 | none stated | not extracted yet |
| Evaluation of Grape Seed Formulation as an Adjunct to Scaling and Root Planing on Oxidative Stress, Inflammatory Status and Glycaemic Control in… Acharya 2021 · Acharya Sameekshya, Gujjari Sheela Kumar, et al. · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH DOI:10.7860/jcdr/2021/45235.14792 | 2021 | 2 | none stated | not extracted yet |
| Local application of curcumin-loaded nanoparticles as an adjunct to scaling and root planing in periodontitis: Randomized, placebo-controlled,… Pérez-Pacheco et al., 2021 · Pérez-Pacheco Cindy Grace, Fernandes Natalie Ap Rodrigues, et al. · Clinical oral investigations PMID:33125518 | 2021 | 2 | 1 | not extracted yet |
| A comparison of the efficacy of scaling and root planning with application of pomegranate chip, pomegranate gel, and scaling and root planing in… Tyagi 2021 · Tyagi Prashant, Dodwad Vidya, et al. · Journal of Indian Society of Periodontology PMID:33642740 | 2021 | 2 | none stated | not extracted yet |
| Using ginger supplement in adjunct with non-surgical periodontal therapy improves metabolic and periodontal parameters in patients with type 2… Gholinezhad 2020 · Gholinezhad Hasan, Bazyar Hadi, et al. · Journal of Herbal Medicine DOI:10.1016/j.hermed.2019.100315 | 2020 | 2 | none stated | not extracted yet |
| Comparative evaluation of 2% turmeric extract with nanocarrier and 1% chlorhexidine gel as an adjunct to scaling and root planing in patients with… Guru et al., 2020 · Guru Sanjeela Rakshith, Reddy K Adithya, et al. · Journal of Indian Society of Periodontology PMID:32773975 | 2020 | 2 | 1 | not extracted yet |
| Efficacy of an herbal antioxidant as an adjunct to nonsurgical periodontal therapy on procalcitonin levels in smokers with chronic periodontitis. Sravya 2019 · Sravya M V N, Koduganti Rekha Rani, et al. · Journal of Indian Society of Periodontology PMID:31543616 | 2019 | 2 | none stated | not extracted yet |
| Efficacy of Curcumin as an Adjunct to Scaling and Root Planing in Chronic Periodontitis Patients: A Randomized Controlled Clinical Trial. Raghava et al., 2019 · Raghava Kepu V, Sistla Kalyani P, et al. · The journal of contemporary dental practice PMID:31597806 | 2019 | 2 | 1 | not extracted yet |
| Evaluation of Turmeric Chip Compared with Chlorhexidine Chip as a Local Drug Delivery Agent in the Treatment of Chronic Periodontitis: A Split Mouth… Singh et al., 2018 · Singh Abhilasha, Sridhar Raja, et al. · Journal of alternative and complementary medicine (New York, N.Y.) PMID:28731780 | 2018 | 2 | 1 | not extracted yet |
| Herbal anti-inflammatory immunomodulators as host modulators in chronic periodontitis patients: a randomised, double-blind, placebo-controlled,… Deore 2014 · Deore Girish D, Gurav Abhijit N, et al. · Journal of periodontal & implant science PMID:24778901 | 2014 | 2 | none stated | not extracted yet |
| Efficacy of a local-drug delivery gel containing extracts of Quercus brantii and Coriandrum sativum as an adjunct to scaling and root planing in… Yaghini 2014 · Yaghini Jaber, Shahabooei Mohammad, et al. · Journal of research in pharmacy practice PMID:25114940 | 2014 | 2 | none stated | not extracted yet |
| Clinical effects of subgingivally delivered spirulina gel in chronic periodontitis cases: a placebo controlled clinical trial. Mahendra 2013 · Mahendra Jaideep, Mahendra Little, et al. · Journal of clinical and diagnostic research : JCDR PMID:24298522 | 2013 | 2 | none stated | not extracted yet |
| Diagnosis of chlamydial infection in pregnant women using the Testpack Chlamydia diagnostic kit. Gencer 2014 · Grossman J H, Rivlin M E, et al. · Obstetrics and gynecology PMID:2014100 | 1991 | 2 | none stated | not extracted yet |
| Solvent use as a precursor to intravenous drug abuse. Golding 2022 · Dinwiddie S H, Reich T, et al. · Comprehensive psychiatry PMID:2022112 | 1991 | 2 | none stated | not extracted yet |
| Multiple myeloma and oat cell carcinoma. Kurdi 2016 · Smith A G, Cumming R L · Journal of clinical pathology PMID:201672 | 1977 | 2 | none stated | not extracted yet |
| Saini et al., 2021 matched by author and year (probable) | NR | 2 | 1 | not extracted yet |
| Evaluation of Ocimum sanctum local drug delivery as an adjunct to scaling and root planing in the treatment of chronic periodontitis: A clinical and… Thippeswamy et al., 2025 · Jannareddy Thippeswamy Madhushree, Pawar Chandrashekara Rao Deepika, et al. · International Journal of Nutrition, Pharmacology, Neurological Diseases DOI:10.4103/ijnpnd.ijnpnd_50_24 | 2025 | 1 | none stated | not extracted yet |
| Home Efficacy of a Postbiotic-Based Gel Compared with a Gel Without Active Ingredients for the Treatment of Gingival Inflammation in Patients with… Scribante et al., 2025 · Scribante Andrea, Appendino Paolo, et al. · Dentistry journal PMID:39996936 | 2025 | 1 | none stated | not extracted yet |
| Clinical Study Comparing Herbal Plant Extract as a Supportive Treatment for Chronic Periodontitis. Sanjay et al., 2025 · Sanjay Lagdive Sushma, Rukhshana N Shaikh, et al. · Journal of pharmacy & bioallied sciences PMID:40511098 | 2025 | 1 | none stated | not extracted yet |
| Punica granatum: An Adjunct in the Non-Surgical Management of Chronic Periodontitis. Pauly et al., 2025 · Pauly Alina, Kumar R Vinaya, et al. · Journal of pharmacy & bioallied sciences PMID:40655708 | 2025 | 1 | none stated | not extracted yet |
| Clinical and Microbiological Study on Local Application of an Ozonated Olive Oil Gel in the Periodontal Pockets: A Randomized Double-Blind Trial. Grassi et al., 2025 · Grassi Roberta, Ciccone Fabio, et al. · Journal of clinical medicine PMID:40806807 | 2025 | 1 | none stated | not extracted yet |
| Impact of systemic resveratrol on non-surgical periodontal treatment of smokers: A 12-month randomized clinical trial. Lucchesi et al., 2025 · Lucchesi Vanessa Haguihara, Giorgetti Ana Paula Oliveira, et al. · Clinical oral investigations PMID:40884630 | 2025 | 1 | none stated | not extracted yet |
| Microbiological and Clinical Short-Term Evaluation of the Efficacy of an Herbal Tincture as an Adjunctive Treatment in the Management of Stage II,… Petrović et al., 2025 · Petrović Milica, Kesić Ljiljana, et al. · Pathogens (Basel, Switzerland) PMID:41011761 | 2025 | 1 | none stated | not extracted yet |
| The adjunctive effect of frankincense extract gel to nonsurgical treatment of chronic periodontitis: a randomized clinical study Yousef et al., 2024 · Yousef Doaa A., Eleknawy Engy, et al. · Tanta Dental Journal DOI:10.4103/tdj.tdj_28_24 | 2024 | 1 | none stated | not extracted yet |
| Effect of a multinutrient supplement as an adjunct to nonsurgical treatment of periodontitis: A randomized placebo-controlled clinical trial. Laky et al., 2023 · Laky Brenda, Bruckmann Corinna, et al. · Journal of periodontology PMID:37439597 | 2024 | 1 | none stated | not extracted yet |
| Comparison of the effectiveness of Morus alba and chlorhexidine gels as an adjunct to scaling and root planing on stage II periodontitis - A… Gunjal et al., 2024 · Gunjal Shilpa, Hampiholi Vinuta, et al. · International journal of dental hygiene PMID:38225885 | 2024 | 1 | none stated | not extracted yet |
| Assessment of the Efficiency of Tulsi Extract as a Locally Administered Medication Agent and Its Comparison With Curcumin in the Treatment of… Agrawal et al., 2024 · Agrawal Ankita, Sharma Anant Ragav, et al. · Cureus PMID:38523946 | 2024 | 1 | none stated | not extracted yet |
| Efficacy of Locally Delivered Aloe Vera Hydrogel in Patients With Chronic Periodontitis: A Prospective Clinical Study. Katariya et al., 2024 · Katariya Chanchal, Rajasekar Arvina · Cureus PMID:38803761 | 2024 | 1 | none stated | not extracted yet |
| Midazolam-Induced Seizure-Like Activity in Five Neonates: A case series. Al-Bayaty et al., 2024 · Shaker Heba, Al-Amrani Fatema, et al. · Sultan Qaboos University medical journal PMID:39234330 | 2024 | 1 | none stated | not extracted yet |
| Beneficial effects of cranberry juice enriched with omega-3 fatty acids in patients with type 2 diabetic and periodontal disease: A randomized pilot… Ashrafzadeh et al., 2024 · Ashrafzadeh Elnaz, Babaei Hossein, et al. · Journal of advanced periodontology & implant dentistry PMID:39758261 | 2024 | 1 | none stated | not extracted yet |
| Comparative Evaluation of Subgingivally Delivered Tetracycline Fibers and Aloe Vera Gel as an Adjunct to Scaling and Root Planing in Treatment of… Thakuria et al., 2024 · Thakuria Anurag, Agarwal Swati, et al. · Journal of pharmacy & bioallied sciences PMID:39926756 | 2024 | 1 | none stated | not extracted yet |
| Effect of Hesperidin as an Adjunct to Scaling and Root Planing on Clinical Parameters and Serum C-Reactive Protein Level in Chronic Periodontitis: A… Shirodkar et al., 2024 · Shirodkar Supriya, Vasani Amit, et al. · Journal of pharmacy & bioallied sciences PMID:39926929 | 2024 | 1 | none stated | not extracted yet |