Primary study · included by 2 reviews

Local application of curcumin-loaded nanoparticles as an adjunct to scaling and root planing in periodontitis: Randomized, placebo-controlled, double-blind split-mouth clinical trial.

Pérez-Pacheco et al., 2021 · Pérez-Pacheco Cindy Grace, Fernandes Natalie Ap Rodrigues, Primo Fernando Lucas, et al. · Clinical oral investigations · 2021

Included by

Do Adjunctive Therapies with Natural Products Improve Periodontal Clinical Parameters After Non-Surgical Treatment? A Systematic Review and Meta-Analysis.

Non-Cochrane · intervention · 2026 · cited as Pérez-Pacheco et al., 2021 · Table 2 (ref 58)

The review does not say which of its outcomes this study informs.

Local curcumin/turmeric-derived delivery adjunctive to scaling and root planing for periodontitis: a systematic review and meta-analysis.

Non-Cochrane · intervention · 2026 · cited as Perez-Pacheco 2021 · Supplementary Table S1 and S3; reference list

Outcome this study informs	Pooled effect	Evidence	Certainty
Probing pocket depth (PPD) reduction, mean difference in mm (negative favors curcumin) Subgingivally delivered curcumin/turmeric-derived formulation (gel, chip, strip, in situ gel, nanoparticle) adjunctive to SRP vs Inactive control (SRP alone, placebo or empty vehicle) · Longest available follow-up	MD -0.46 [-0.68, -0.24]	15 studies	Low

2 including reviews in total.