Non-Cochrane · DTA · PM42890841
Oral-fluid inflammatory and oxidative-stress biomarkers for peri-implantitis in Asian adults: a systematic review and stratified random-effects meta-analysis.
Feng Lina, Zhang Lei, He Wenfeng, et al. · Open life sciences · 2026 · PubMed · doi:10.1515/biol-2025-1360
Findings
Population Asian adults with peri-implantitis and healthy controls
29 findings
| Oral-fluid biomarkers in peri-implantitis | Healthy peri-implant controls | Meta-regression coefficient for biomarker concentration SMD Analysis unit: patient | Regression coefficient 0.183 [-1.792, 2.159] GRADE not reported Studies not reported |
| Oral-fluid biomarkers in peri-implantitis | Healthy peri-implant controls | Combined inflammatory biomarker concentrations Saliva | SMD 3.06 [2.61, 3.5] GRADE not reported 2 studies |
| Oral-fluid biomarkers in peri-implantitis | Healthy peri-implant controls | Meta-regression coefficient for biomarker concentration SMD PI sample size | Regression coefficient -0.021 [-0.045, 0.003] GRADE not reported Studies not reported |
| Oral-fluid biomarkers in peri-implantitis | Healthy peri-implant controls | IL-1β concentration Excluding highest absolute SMD study | SMD 1.99 [1.71, 2.26] GRADE not reported Studies not reported |
| Oral-fluid biomarkers in peri-implantitis | Healthy peri-implant controls | Meta-regression coefficient for biomarker concentration SMD Biomarker class: oxidative-stress regulator | Regression coefficient -7.531 [-13.028, -2.034] GRADE not reported Studies not reported |
| Oral-fluid biomarkers in peri-implantitis | Healthy peri-implant controls | TNF-α concentration Excluding highest absolute SMD study | SMD 2.92 [2.52, 3.32] GRADE not reported Studies not reported |
| Oral-fluid biomarkers in peri-implantitis | Healthy peri-implant controls | Combined inflammatory biomarker concentrations 2017 diagnostic criteria | SMD 2.43 [-4.76, 9.62] GRADE not reported 2 studies |
| Oral-fluid biomarkers in peri-implantitis | Healthy peri-implant controls | Meta-regression coefficient for biomarker concentration SMD Specimen type: saliva | Regression coefficient 0.87 [-1.127, 2.867] GRADE not reported Studies not reported |
| Oral-fluid biomarkers in peri-implantitis | Healthy peri-implant controls | Combined inflammatory biomarker concentrations Implant-level | SMD 2.62 [2.35, 2.9] GRADE not reported 4 studies |
| Oral-fluid biomarkers in peri-implantitis | Healthy peri-implant controls | Combined inflammatory biomarker concentrations Non-2017 diagnostic criteria | SMD 2.7 [2.36, 3.04] GRADE not reported 10 studies |
| Oral-fluid biomarkers in peri-implantitis | Healthy peri-implant controls | SIRT1 diagnostic discrimination Random-effects pooled AUC | AUC 0.867 [0.66, 0.965] GRADE not reported 2 studies |
| Oral-fluid biomarkers in peri-implantitis | Healthy peri-implant controls | Meta-regression coefficient for biomarker concentration SMD Specimen type: PISF | Regression coefficient 0.765 [-2.059, 3.589] GRADE not reported Studies not reported |
| Oral-fluid biomarkers in peri-implantitis | Healthy peri-implant controls | IL-6 concentration Excluding studies with total sample size below 40 | SMD 3.19 [2.93, 3.44] GRADE not reported Studies not reported |
| Oral-fluid biomarkers in peri-implantitis | Healthy peri-implant controls | Combined inflammatory biomarker concentrations Patient-level | SMD 2.45 [1.93, 2.97] GRADE not reported 7 studies |
| Oral-fluid biomarkers in peri-implantitis | Healthy peri-implant controls | IL-6 concentration Random-effects primary model | SMD 3.19 [3.05, 3.33] GRADE not reported 9 studies · 623 participants |
| Oral-fluid biomarkers in peri-implantitis | Healthy peri-implant controls | IL-1β concentration in PICF Random-effects primary model | SMD 2.09 [1.76, 2.42] GRADE not reported 7 studies · 358 participants |
| Oral-fluid biomarkers in peri-implantitis | Healthy peri-implant controls | Combined inflammatory biomarker concentrations PICF | SMD 2.46 [2.07, 2.85] GRADE not reported 10 studies |
| Oral-fluid biomarkers in peri-implantitis | Healthy peri-implant controls | TNF-α concentration Excluding studies with total sample size below 40 | SMD 3.09 [2.75, 3.44] GRADE not reported Studies not reported |
| Oral-fluid biomarkers in peri-implantitis | Healthy peri-implant controls | Meta-regression coefficient for biomarker concentration SMD Total sample size | Regression coefficient -0.011 [-0.024, 0.002] GRADE not reported Studies not reported |
| Oral-fluid biomarkers in peri-implantitis | Healthy peri-implant controls | TNF-α concentration Common-effect model | SMD 3.06 [2.74, 3.38] GRADE not reported 6 studies · 344 participants |
| Oral-fluid biomarkers in peri-implantitis | Healthy peri-implant controls | IL-6 concentration Common-effect model | SMD 3.19 [2.95, 3.43] GRADE not reported 9 studies · 623 participants |
| Oral-fluid biomarkers in peri-implantitis | Healthy peri-implant controls | TNF-α concentration Random-effects primary model | SMD 3.06 [2.85, 3.28] GRADE not reported 6 studies · 344 participants |
| Oral-fluid biomarkers in peri-implantitis | Healthy peri-implant controls | IL-1β concentration in PICF Common-effect model | SMD 2.02 [1.75, 2.29] GRADE not reported 7 studies · 358 participants |
| Oral-fluid biomarkers in peri-implantitis | Healthy peri-implant controls | Meta-regression coefficient for biomarker concentration SMD Publication year | Regression coefficient -0.051 [-0.207, 0.105] GRADE not reported Studies not reported |
| Oral-fluid biomarkers in peri-implantitis | Healthy peri-implant controls | IL-6 concentration Excluding highest absolute SMD study | SMD 3.17 [2.93, 3.42] GRADE not reported Studies not reported |
| Oral-fluid biomarkers in peri-implantitis | Healthy peri-implant controls | Meta-regression coefficient for biomarker concentration SMD Baseline severity | Regression coefficient 0 [-0.0, 0.0] GRADE not reported Studies not reported |
| Oral-fluid biomarkers in peri-implantitis | Healthy peri-implant controls | IL-1β concentration Excluding studies with total sample size below 40 | SMD 1.92 [1.63, 2.21] GRADE not reported Studies not reported |
| Oral-fluid biomarkers in peri-implantitis | Healthy peri-implant controls | Meta-regression coefficient for biomarker concentration SMD Analysis unit: site | Regression coefficient 3.204 [-2.332, 8.74] GRADE not reported Studies not reported |
| Oral-fluid biomarkers in peri-implantitis | Healthy peri-implant controls | Meta-regression coefficient for biomarker concentration SMD Biomarker class: inflammation | Regression coefficient -5.872 [-11.071, -0.674] GRADE not reported Studies not reported |
Included primary studies 13
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Chen 2020 matched by author and year (probable) | NR | 2 other reviews | not stated | not extracted yet |
| Yang 2024 matched by author and year (probable) | NR | 2 other reviews | PM42890841-P8-O1 | not extracted yet |
| Abduljabbar 2019 Relationship between self-rated pain and peri-implant clinical, radiographic and whole salivary inflammatory markers among patients with… PMID:31709730 | 2019 | this review only | not stated | not extracted yet |
| Al-Askar 2018 Clinical and Radiographic Peri-Implant Parameters and Whole Salivary Interleukin-1β and Interleukin-6 Levels among Type-2 Diabetic and… PMID:29490310 | 2018 | this review only | not stated | not extracted yet |
| Bhukal 2025 Assessing the Significance of Interleukin-6, Interleukin-10, and Tumor Necrosis Factor-Alpha in Peri-Implantitis Development: A Biomarker… PMID:40959363 | 2025 | this review only | not stated | not extracted yet |
| Gao 2018 Differential expressions of biomarkers in gingival crevicular fluid of Han and Uygur populations with peri-implantitis. PMID:29668623 | 2018 | this review only | not stated | not extracted yet |
| Gundogar 2021 The Effect of Periodontal and Peri-Implanter Health on IL-1β and TNF-α Levels in Gingival Crevicular and Peri-Implanter Sulcus Fluid: a… DOI:10.15517/ijds.2021.44071 | 2020 | this review only | not stated | not extracted yet |
| Luo 2011 Expression of HMGB1 and HMGN2 in gingival tissues, GCF and PICF of periodontitis patients and peri-implantitis. PMID:21570059 | 2011 | this review only | not stated | not extracted yet |
| Saxena 2025 Evaluating the role of inflammatory biomarkers as a diagnostic tool in peri-implantitis. PMID:40008071 | 2025 | this review only | not stated | not extracted yet |
| Wang 2022 Peri-implant crevicular fluid SIRT1 levels decrease in patients with peri-implant inflammatory: A prospective observational study. PMID:35781023 | 2022 | this review only | not stated | not extracted yet |
| Yaghobee 2013 Comparison of interleukin-1β levels in gingival crevicular fluid and peri-implant crevicular fluid and its relationship with clinical… PMID:23724197 | 2013 | this review only | not stated | not extracted yet |
| Yaghobee 2014 Assessment of interleukin-1beta and interleukin-6 in the crevicular fluid around healthy implants, implants with peri-implantitis, and… PMID:25368834 | 2014 | this review only | not stated | not extracted yet |
| Zhang 2005 Increased IL-6 Levels in Peri-Implant Crevicular Fluid Correlate with Peri-Implantitis DOI:10.3353/omp.10.95 | 2005 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Asian adults with peri-implantitis, peri-implant mucositis, or healthy implants | Asian adults with peri-implantitis vs healthy controls from China, India, Iran, Saudi Arabia and Turkey (n=13 studies) |
| Intervention | Measurement of biomarkers (inflammatory cytokines or oxidative-stress regulators) in PICF or saliva | Peri-implantitis; IL-1beta (n=7), IL-6 (n=9), TNF-alpha (n=6) in PICF or saliva; SIRT1 (n=2) |
| Comparison | Healthy peri-implant controls or patients without peri-implantitis | Healthy peri-implant controls (n=13) |
| Outcomes | Quantitative biomarker concentrations (mean, SD) and/or diagnostic performance (ROC, AUC, sensitivity, specificity) | IL-1beta SMD (n=7, 145 PI vs 213 controls); IL-6 SMD (n=9, 274 vs 349); TNF-alpha SMD (n=6, 144 vs 200); SIRT1 pooled AUC (n=2) |
| Study designs | Observational clinical studies (cross-sectional, case-control, cohort) | Observational cross-sectional/case-control studies (n=13) |
| Timing | Not specified | Not specified |