Non-Cochrane · intervention · PM42622053
Pre- and Post-treatment Changes in Systemic Inflammatory Biomarkers After Oral Appliance Therapy for Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis.
Chaiwala Arwa Hussain, Chaiwala Hussain, Franklin Sachin, et al. · Cureus · 2026 · PubMed · doi:10.7759/cureus.113045
Findings
Population Adults with obstructive sleep apnea
3 findings
| Oral appliance therapy (mandibular advancement devices) | Pre-treatment baseline (pre- vs post-treatment change) | Systemic inflammatory biomarker: C-reactive protein (CRP) Post-treatment (2 months to 6 months of appliance use) | MD -0.579 [-1.18, 0.0261] Low Downgraded: risk of bias, imprecision 2 studies |
| Oral appliance therapy (mandibular advancement devices) | Pre-treatment baseline (pre- vs post-treatment change) | Systemic inflammatory biomarker: Interleukin-6 (IL-6) Post-treatment (2 months to 6 months of appliance use) | MD 0.209 [-0.132, 0.55] Low Downgraded: risk of bias, imprecision 2 studies |
| Oral appliance therapy (mandibular advancement devices) | Pre-treatment baseline (pre- vs post-treatment change) | Systemic inflammatory biomarker: TNF-alpha (TNF-α) Post-treatment (2 months to 6 months of appliance use) | MD -0.287 [-1.2, 0.622] Low Downgraded: risk of bias, imprecision 2 studies |
Included primary studies 6
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Fernandez-Julian 2017 Impact of an oral appliance on obstructive sleep apnea severity, quality of life, and biomarkers. PMID:29152745 | 2018 | this review only | not stated | not extracted yet |
| Hedberg 2020 Effects of oral appliance treatment on inflammatory biomarkers in obstructive sleep apnea: A randomised controlled trial. PMID:33300239 | 2021 | this review only | not stated | not extracted yet |
| Niżankowska-Jędrzejczyk 2014 Modulation of inflammatory and hemostatic markers in obstructive sleep apnea patients treated with mandibular advancement splints: a… PMID:24634622 | 2014 | this review only | not stated | not extracted yet |
| Peres 2023 Intraoral appliance treatment modulates inflammatory markers and oxidative damage in elderly with sleep apnea. PMID:39661789 | 2024 | this review only | Systemic inflammatory biomarker: TNF-alpha (TNF-α); Systemic inflammatory biomarker: Interleukin-6 (IL-6) | not extracted yet |
| Recoquillon 2018 Effect of mandibular advancement therapy on inflammatory and metabolic biomarkers in patients with severe obstructive sleep apnoea: a… PMID:30366971 | 2019 | this review only | Systemic inflammatory biomarker: TNF-alpha (TNF-α); Systemic inflammatory biomarker: C-reactive protein (CRP); Systemic inflammatory biomarker: Interleukin-6 (IL-6) | not extracted yet |
| Yalamanchali 2014 Impact of mandibular advancement devices on C-reactive protein levels in patients with obstructive sleep apnea. PMID:25429861 | 2015 | this review only | Systemic inflammatory biomarker: C-reactive protein (CRP) | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Adults with obstructive sleep apnea receiving oral appliances (mandibular advancement devices) | 290 adults with mild to severe OSA (n=6 studies) |
| Intervention | Oral appliance therapy | Mandibular advancement splint or device, intraoral appliance (n=6) |
| Comparison | Not specified (before versus after treatment; sham or controls where available) | Pre-treatment baseline, sham device, passive appliance or untreated controls |
| Outcomes | Systemic inflammatory markers before and after treatment: CRP, interleukins, TNF-α, other cytokines | CRP, TNF-α, IL-6 pooled (2 studies each); IL-1β, IL-10, other markers narrative |
| Study designs | RCTs and observational designs, prospective or retrospective; adults; English language | 2 RCTs, 1 parallel controlled trial, 1 case-control, 1 quasi-experimental, 1 retrospective study |
| Timing | Not specified | 2 to 6 months of oral appliance therapy |