evidencegaps
Primary study · included by 1 review

Intraoral appliance treatment modulates inflammatory markers and oxidative damage in elderly with sleep apnea.

Peres 2023 · Peres Alessandra, Rosa João Carlos Fraga da, Ribeiro Joane Severo, et al. · Brazilian oral research · 2024

Included by

Pre- and Post-treatment Changes in Systemic Inflammatory Biomarkers After Oral Appliance Therapy for Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis.
Non-Cochrane · intervention · 2026 · cited as Peres 2023 · Table 1; Table 2
Outcome this study informsPooled effectEvidenceCertainty
Systemic inflammatory biomarker: Interleukin-6 (IL-6)
Oral appliance therapy (mandibular advancement devices) vs Pre-treatment baseline (pre- vs post-treatment change) · Post-treatment (2 months to 6 months of appliance use)
MD 0.209 [-0.132, 0.55]2 studiesLow
Systemic inflammatory biomarker: TNF-alpha (TNF-α)
Oral appliance therapy (mandibular advancement devices) vs Pre-treatment baseline (pre- vs post-treatment change) · Post-treatment (2 months to 6 months of appliance use)
MD -0.287 [-1.2, 0.622]2 studiesLow

1 including review in total.