Primary study · included by 1 review

Effect of mandibular advancement therapy on inflammatory and metabolic biomarkers in patients with severe obstructive sleep apnoea: a randomised controlled trial.

Recoquillon 2018 · Recoquillon Sylvain, Pépin Jean-Louis, Vielle Bruno, et al. · Thorax · 2019

Included by

Pre- and Post-treatment Changes in Systemic Inflammatory Biomarkers After Oral Appliance Therapy for Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis.

Non-Cochrane · intervention · 2026 · cited as Recoquillon 2018 · Table 1; Table 2

Outcome this study informs	Pooled effect	Evidence	Certainty
Systemic inflammatory biomarker: C-reactive protein (CRP) Oral appliance therapy (mandibular advancement devices) vs Pre-treatment baseline (pre- vs post-treatment change) · Post-treatment (2 months to 6 months of appliance use)	MD -0.579 [-1.18, 0.0261]	2 studies	Low
Systemic inflammatory biomarker: Interleukin-6 (IL-6) Oral appliance therapy (mandibular advancement devices) vs Pre-treatment baseline (pre- vs post-treatment change) · Post-treatment (2 months to 6 months of appliance use)	MD 0.209 [-0.132, 0.55]	2 studies	Low
Systemic inflammatory biomarker: TNF-alpha (TNF-α) Oral appliance therapy (mandibular advancement devices) vs Pre-treatment baseline (pre- vs post-treatment change) · Post-treatment (2 months to 6 months of appliance use)	MD -0.287 [-1.2, 0.622]	2 studies	Low

1 including review in total.